Cargando…

Design, synthesis and crystallographic analysis of nitrile-based broad-spectrum peptidomimetic inhibitors for coronavirus 3C-like proteases

Coronaviral infection is associated with up to 5% of respiratory tract diseases. The 3C-like protease (3CL(pro)) of coronaviruses is required for proteolytic processing of polyproteins and viral replication, and is a promising target for the development of drugs against coronaviral infection. We des...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chuck, Chi-Pang, Chen, Chao, Ke, Zhihai, Chi-Cheong Wan, David, Chow, Hak-Fun, Wong, Kam-Bo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier Masson SAS. 2013
Materias:	Short Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7115530/ https://www.ncbi.nlm.nih.gov/pubmed/23202846 http://dx.doi.org/10.1016/j.ejmech.2012.10.053

Ejemplares similares

Profiling of Substrate Specificities of 3C-Like Proteases from Group 1, 2a, 2b, and 3 Coronaviruses
por: Chuck, Chi-Pang, et al.
Publicado: (2011)

Novel Nitrile Peptidomimetics for Treating COVID-19
por: Chia, C. S. Brian
Publicado: (2022)

Profiling of Substrate Specificity of SARS-CoV 3CL(pro)
por: Chuck, Chi-Pang, et al.
Publicado: (2010)

Design, synthesis and biological evaluation of covalent peptidomimetic 3CL protease inhibitors containing nitrile moiety
por: Zhu, Mengwei, et al.
Publicado: (2023)

Targeting papain-like protease for broad-spectrum coronavirus inhibition
por: Yuan, Shuofeng, et al.
Publicado: (2022)

Bioinspired Polydopamine Coatings Facilitate Attachment of Antimicrobial Peptidomimetics with Broad-Spectrum Antibacterial Activity
por: Browne, Katrina, et al.
Publicado: (2022)

Protease inhibitors and their peptidomimetic derivatives as potential drugs
por: Fear, Georgie, et al.
Publicado: (2007)

Broad-spectrum coronavirus 3C-like protease peptidomimetic inhibitors effectively block SARS-CoV-2 replication in cells: Design, synthesis, biological evaluation, and X-ray structure determination
por: Stefanelli, Irina, et al.
Publicado: (2023)

Reversal of the Progression of Fatal Coronavirus Infection in Cats by a Broad-Spectrum Coronavirus Protease Inhibitor
por: Kim, Yunjeong, et al.
Publicado: (2016)

Correction: Reversal of the Progression of Fatal Coronavirus Infection in Cats by a Broad-Spectrum Coronavirus Protease Inhibitor
por: Kim, Yunjeong, et al.
Publicado: (2016)

Broad-Spectrum Allosteric Inhibition of Herpesvirus Proteases
por: Gable, Jonathan E., et al.
Publicado: (2014)

Inhibition of the severe acute respiratory syndrome 3CL protease by peptidomimetic α,β-unsaturated esters
por: Shie, Jiun-Jie, et al.
Publicado: (2005)

Peptidomimetic Oligomers Targeting Membrane Phosphatidylserine Exhibit Broad Antiviral Activity
por: Tate, Patrick M., et al.
Publicado: (2023)

Crystallization and preliminary crystallographic study of human coronavirus NL63 main protease in complex with an inhibitor
por: Wang, Fenghua, et al.
Publicado: (2014)

Development of Broad‐Spectrum Halomethyl Ketone Inhibitors Against Coronavirus Main Protease 3CL(pro)
por: Bacha, Usman, et al.
Publicado: (2008)

Expression of SARS-coronavirus spike glycoprotein in Pichia pastoris
por: Chuck, Chi-Pang, et al.
Publicado: (2008)

An Overview of Severe Acute Respiratory Syndrome–Coronavirus (SARS-CoV) 3CL Protease Inhibitors: Peptidomimetics and Small Molecule Chemotherapy
por: Pillaiyar, Thanigaimalai, et al.
Publicado: (2016)

Peptidomimetics II
por: Lubell, William D
Publicado: (2016)

Structure-Based Discovery and Structural Basis of a Novel Broad-Spectrum Natural Product against the Main Protease of Coronavirus
por: Zhang, Yuting, et al.
Publicado: (2022)

Computational study on peptidomimetic inhibitors against SARS-CoV-2 main protease
por: Somboon, Tuanjai, et al.
Publicado: (2021)

Protease inhibitors broadly effective against feline, ferret and mink coronaviruses
por: Perera, Krishani Dinali, et al.
Publicado: (2018)

Ultralarge Virtual Screening Identifies SARS-CoV-2 Main Protease Inhibitors with Broad-Spectrum Activity against Coronaviruses
por: Luttens, Andreas, et al.
Publicado: (2022)

Allosteric Binding Sites of the SARS-CoV-2 Main Protease: Potential Targets for Broad-Spectrum Anti-Coronavirus Agents
por: Alzyoud, Lara, et al.
Publicado: (2022)

Conserved coronavirus proteins as targets of broad-spectrum antivirals
por: Melo-Filho, Cleber C., et al.
Publicado: (2022)

The Advances of Broad-Spectrum and Hot Anti-Coronavirus Drugs
por: Zeng, Sen, et al.
Publicado: (2022)

Novel broad-spectrum activity-based probes to profile malarial cysteine proteases
por: Tan, Michele S. Y., et al.
Publicado: (2020)

Peptidomimetics in cancer targeting
por: Gomari, Mohammad Mahmoudi, et al.
Publicado: (2022)

Design of Wide-Spectrum Inhibitors Targeting Coronavirus Main Proteases
por: Yang, Haitao, et al.
Publicado: (2005)

Cysteine protease inhibition by nitrile-based inhibitors: a computational study
por: Quesne, Matthew G., et al.
Publicado: (2013)

Preliminary crystallographic analysis of avian infectious bronchitis virus main protease
por: Li, Jun, et al.
Publicado: (2006)

Assessment of Proton-Coupled Conformational Dynamics of SARS and MERS Coronavirus Papain-like Proteases: Implication for Designing Broad-Spectrum Antiviral Inhibitors
por: Henderson, Jack A., et al.
Publicado: (2020)

Assessment of proton-coupled conformational dynamics of SARS and MERS coronavirus papain-like proteases: Implication for designing broad-spectrum antiviral inhibitors
por: Henderson, Jack A., et al.
Publicado: (2020)

Discovery of 2-Phenylquinolines with Broad-Spectrum Anti-coronavirus Activity
por: Nizi, Maria Giulia, et al.
Publicado: (2022)

Investigation of the Compatibility between Warheads and Peptidomimetic Sequences of Protease Inhibitors—A Comprehensive Reactivity and Selectivity Study
por: Müller, Patrick, et al.
Publicado: (2023)

Correction: Novel broad-spectrum activity-based probes to profile malarial cysteine proteases
por: Tan, Michele S. Y., et al.
Publicado: (2020)

Correction: Design of Wide-Spectrum Inhibitors Targeting Coronavirus Main Proteases
por: Yang, Haitao, et al.
Publicado: (2005)

Anti-trypanosomal activity of non-peptidic nitrile-based cysteine protease inhibitors
por: Burtoloso, Antonio C. B., et al.
Publicado: (2017)

Phycobilins as Potent Food Bioactive Broad-Spectrum Inhibitors Against Proteases of SARS-CoV-2 and Other Coronaviruses: A Preliminary Study
por: Pendyala, Brahmaiah, et al.
Publicado: (2021)

Molecular cloning, expression, purification and crystallographic analysis of PRRSV 3CL protease
por: Tian, Xinsheng, et al.
Publicado: (2007)

Crystallographic and electrophilic fragment screening of the SARS-CoV-2 main protease
por: Douangamath, Alice, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_29mvthdf3o2lrif02r7b943lf2