A prime-boost vaccination protocol optimizes immune responses against the nucleocapsid protein of the SARS coronavirus

Severe acute respiratory syndrome (SARS) is a serious infectious disease caused by the SARS coronavirus. We assessed the potential of prime-boost vaccination protocols based on the nucleocapsid (NC) protein co-administered with a derivative of the mucosal adjuvant MALP-2 or expressed by modified Vac...

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Detalles Bibliográficos
Autores principales: Schulze, Kai, Staib, Caroline, Schätzl, Hermann M., Ebensen, Thomas, Erfle, Volker, Guzman, Carlos A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier Ltd. 2008
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7115531/
https://www.ncbi.nlm.nih.gov/pubmed/18805454
http://dx.doi.org/10.1016/j.vaccine.2008.09.006
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author Schulze, Kai
Staib, Caroline
Schätzl, Hermann M.
Ebensen, Thomas
Erfle, Volker
Guzman, Carlos A.
author_facet Schulze, Kai
Staib, Caroline
Schätzl, Hermann M.
Ebensen, Thomas
Erfle, Volker
Guzman, Carlos A.
author_sort Schulze, Kai
collection PubMed
description Severe acute respiratory syndrome (SARS) is a serious infectious disease caused by the SARS coronavirus. We assessed the potential of prime-boost vaccination protocols based on the nucleocapsid (NC) protein co-administered with a derivative of the mucosal adjuvant MALP-2 or expressed by modified Vaccinia virus Ankara (MVA–NC) to stimulate humoral and cellular immune responses at systemic and mucosal levels. The obtained results demonstrated that strong immune responses can be elicited both at systemic and mucosal levels following a heterologous prime-boost vaccination protocol consisting in priming with NC protein add-mixed with MALP-2 by intranasal route and boosting with MVA–NC by intramuscular route.
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spelling pubmed-71155312020-04-02 A prime-boost vaccination protocol optimizes immune responses against the nucleocapsid protein of the SARS coronavirus Schulze, Kai Staib, Caroline Schätzl, Hermann M. Ebensen, Thomas Erfle, Volker Guzman, Carlos A. Vaccine Article Severe acute respiratory syndrome (SARS) is a serious infectious disease caused by the SARS coronavirus. We assessed the potential of prime-boost vaccination protocols based on the nucleocapsid (NC) protein co-administered with a derivative of the mucosal adjuvant MALP-2 or expressed by modified Vaccinia virus Ankara (MVA–NC) to stimulate humoral and cellular immune responses at systemic and mucosal levels. The obtained results demonstrated that strong immune responses can be elicited both at systemic and mucosal levels following a heterologous prime-boost vaccination protocol consisting in priming with NC protein add-mixed with MALP-2 by intranasal route and boosting with MVA–NC by intramuscular route. Published by Elsevier Ltd. 2008-12-02 2008-09-19 /pmc/articles/PMC7115531/ /pubmed/18805454 http://dx.doi.org/10.1016/j.vaccine.2008.09.006 Text en Copyright © 2008 Published by Elsevier Ltd. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Schulze, Kai
Staib, Caroline
Schätzl, Hermann M.
Ebensen, Thomas
Erfle, Volker
Guzman, Carlos A.
A prime-boost vaccination protocol optimizes immune responses against the nucleocapsid protein of the SARS coronavirus
title A prime-boost vaccination protocol optimizes immune responses against the nucleocapsid protein of the SARS coronavirus
title_full A prime-boost vaccination protocol optimizes immune responses against the nucleocapsid protein of the SARS coronavirus
title_fullStr A prime-boost vaccination protocol optimizes immune responses against the nucleocapsid protein of the SARS coronavirus
title_full_unstemmed A prime-boost vaccination protocol optimizes immune responses against the nucleocapsid protein of the SARS coronavirus
title_short A prime-boost vaccination protocol optimizes immune responses against the nucleocapsid protein of the SARS coronavirus
title_sort prime-boost vaccination protocol optimizes immune responses against the nucleocapsid protein of the sars coronavirus
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7115531/
https://www.ncbi.nlm.nih.gov/pubmed/18805454
http://dx.doi.org/10.1016/j.vaccine.2008.09.006
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