Recombinant influenza H1, H5 and H9 hemagglutinins containing replaced H3 hemagglutinin transmembrane domain showed enhanced heterosubtypic protection in mice

Influenza A viruses cause annual epidemics and irregular pandemics. A vaccine with heterosubtypic protection (hetero-protection) has been needed. In the present study, various influenza H1, H3, H5, and H9 hemagglutinin (HA) proteins were expressed in insect cells, and then mice were subcutaneously i...

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Detalles Bibliográficos
Autores principales: Liu, Qiliang, Liu, Kang, Xue, Chunyi, Zhou, Jianqiang, Li, Xiaoming, Luo, Dongyu, Zheng, Jing, Xu, Shun, Liu, George Dacai, Cao, Yongchang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7115591/
https://www.ncbi.nlm.nih.gov/pubmed/24704333
http://dx.doi.org/10.1016/j.vaccine.2014.03.058

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