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Influence of intron and exon splicing enhancers on mammalian cell expression of a truncated spike protein of SARS-CoV and its implication for subunit vaccine development

The spike (S) protein of severe acute respiratory syndrome coronavirus (SARS-CoV) is important for vaccine development. A truncated S protein of the TW1 strain, S(TR2) (88 kDa), carrying three S fragments (S74–253, S294–739, and S1129–1255) was investigated to study the influences of intron and exon...

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Detalles Bibliográficos
Autores principales: Chang, Chia-Yin, Hong, Willy W.L., Chong, Pele, Wu, Suh-Chin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2006
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7115599/
https://www.ncbi.nlm.nih.gov/pubmed/16194584
http://dx.doi.org/10.1016/j.vaccine.2005.09.011