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The Canarypox-virus vaccine vector ALVAC triggers the release of IFN-γ by Natural Killer (NK) cells enhancing Th1 polarization

We investigated the mechanism by which ALVAC activates innate immunity. Combining ALVAC with protein antigens significantly augmented antigen-specific IgG2a responses; this was dependent on the presence of bioactive interferon (IFN)-γ. Immuno-depletion of NK cells prior to ALVAC immunisation abrogat...

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Detalles Bibliográficos
Autores principales:	Ryan, Elizabeth J., Harenberg, Anke, Burdin, Nicolas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier Ltd. 2007
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7115637/ https://www.ncbi.nlm.nih.gov/pubmed/17234309 http://dx.doi.org/10.1016/j.vaccine.2006.12.048

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