Adenovirus-based vaccine prevents pneumonia in ferrets challenged with the SARS coronavirus and stimulates robust immune responses in macaques

A ferret model of severe acute respiratory syndrome (SARS)-CoV infection was used to evaluate the efficacy of an adenovirus vaccine. Animals were subjected to heterologous prime-boost using vectors from human serotype 5 and chimpanzee derived adenoviruses (human AdHu5 and chimpanzee AdC7) expressing...

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Detalles Bibliográficos
Autores principales: Kobinger, Gary P., Figueredo, Joanita M., Rowe, Thomas, Zhi, Yan, Gao, Guangping, Sanmiguel, Julio C., Bell, Peter, Wivel, Nelson A., Zitzow, Lois A., Flieder, Douglas B., Hogan, Robert J., Wilson, James M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2007
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7115643/
https://www.ncbi.nlm.nih.gov/pubmed/17559989
http://dx.doi.org/10.1016/j.vaccine.2007.04.065

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