Synthesis and affinity to DNA of phenylbenzoimidazoles and benzoimidazo[1,2-c]quinazolines

Novel N-(benzoimidazophenyl)dialkylaminoalkylamides and 6-dialkylaminoalkylbenzoimidazo[1,2-c]quinazolines were prepared as potential interferon inducers and antiviral agents. They were screened for the DNA affinity by the ethidium bromide displacement assay. It was shown that the lg K(a) values of ...

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Detalles Bibliográficos
Autores principales: Lyakhova, Elena A., Gusyeva, Yulia A., Nekhoroshkova, Julia V., Shafran, Lev M., Lyakhov, Sergey A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Masson SAS. 2009
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7115644/
https://www.ncbi.nlm.nih.gov/pubmed/19349097
http://dx.doi.org/10.1016/j.ejmech.2009.03.004
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author Lyakhova, Elena A.
Gusyeva, Yulia A.
Nekhoroshkova, Julia V.
Shafran, Lev M.
Lyakhov, Sergey A.
author_facet Lyakhova, Elena A.
Gusyeva, Yulia A.
Nekhoroshkova, Julia V.
Shafran, Lev M.
Lyakhov, Sergey A.
author_sort Lyakhova, Elena A.
collection PubMed
description Novel N-(benzoimidazophenyl)dialkylaminoalkylamides and 6-dialkylaminoalkylbenzoimidazo[1,2-c]quinazolines were prepared as potential interferon inducers and antiviral agents. They were screened for the DNA affinity by the ethidium bromide displacement assay. It was shown that the lg K(a) values of the compounds containing tetracyclic benzoimidazo[1,2-c]quinazoline fragment are approximately one order magnitude greater than those of the corresponding acyclic phenylbenzoimidazole derivatives.
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spelling pubmed-71156442020-04-02 Synthesis and affinity to DNA of phenylbenzoimidazoles and benzoimidazo[1,2-c]quinazolines Lyakhova, Elena A. Gusyeva, Yulia A. Nekhoroshkova, Julia V. Shafran, Lev M. Lyakhov, Sergey A. Eur J Med Chem Short Communication Novel N-(benzoimidazophenyl)dialkylaminoalkylamides and 6-dialkylaminoalkylbenzoimidazo[1,2-c]quinazolines were prepared as potential interferon inducers and antiviral agents. They were screened for the DNA affinity by the ethidium bromide displacement assay. It was shown that the lg K(a) values of the compounds containing tetracyclic benzoimidazo[1,2-c]quinazoline fragment are approximately one order magnitude greater than those of the corresponding acyclic phenylbenzoimidazole derivatives. Elsevier Masson SAS. 2009-08 2009-03-21 /pmc/articles/PMC7115644/ /pubmed/19349097 http://dx.doi.org/10.1016/j.ejmech.2009.03.004 Text en Copyright © 2009 Elsevier Masson SAS. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Short Communication
Lyakhova, Elena A.
Gusyeva, Yulia A.
Nekhoroshkova, Julia V.
Shafran, Lev M.
Lyakhov, Sergey A.
Synthesis and affinity to DNA of phenylbenzoimidazoles and benzoimidazo[1,2-c]quinazolines
title Synthesis and affinity to DNA of phenylbenzoimidazoles and benzoimidazo[1,2-c]quinazolines
title_full Synthesis and affinity to DNA of phenylbenzoimidazoles and benzoimidazo[1,2-c]quinazolines
title_fullStr Synthesis and affinity to DNA of phenylbenzoimidazoles and benzoimidazo[1,2-c]quinazolines
title_full_unstemmed Synthesis and affinity to DNA of phenylbenzoimidazoles and benzoimidazo[1,2-c]quinazolines
title_short Synthesis and affinity to DNA of phenylbenzoimidazoles and benzoimidazo[1,2-c]quinazolines
title_sort synthesis and affinity to dna of phenylbenzoimidazoles and benzoimidazo[1,2-c]quinazolines
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7115644/
https://www.ncbi.nlm.nih.gov/pubmed/19349097
http://dx.doi.org/10.1016/j.ejmech.2009.03.004
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