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Highly convergent synthesis and antiviral activity of (E)-but-2-enyl nucleoside phosphonoamidates

Several hitherto unknown (E)-but-2-enyl nucleoside phosphonoamidate analogs (ANPs) were prepared directed with nitrogen reagents by cross-metathesis in water-under ultrasound irradiation. Two diastereoisomers were formally identified by X-ray diffraction. These compounds were evaluated against a lar...

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Detalles Bibliográficos
Autores principales:	Bessières, Maxime, Hervin, Vincent, Roy, Vincent, Chartier, Agnès, Snoeck, Robert, Andrei, Graciela, Lohier, Jean-François, Agrofoglio, Luigi A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier Masson SAS. 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7115695/ https://www.ncbi.nlm.nih.gov/pubmed/29407990 http://dx.doi.org/10.1016/j.ejmech.2018.01.086

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