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Current concepts in the prevention of pathogen transmission via blood/plasma-derived products for bleeding disorders()

The pathogen safety of blood/plasma-derived products has historically been a subject of significant concern to the medical community. Measures such as donor selection and blood screening have contributed to increase the safety of these products, but pathogen transmission does still occur. Reasons fo...

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Autores principales: Di Minno, Giovanni, Perno, Carlo Federico, Tiede, Andreas, Navarro, David, Canaro, Mariana, Güertler, Lutz, Ironside, James W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier Ltd. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7115716/
https://www.ncbi.nlm.nih.gov/pubmed/26381318
http://dx.doi.org/10.1016/j.blre.2015.07.004
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author Di Minno, Giovanni
Perno, Carlo Federico
Tiede, Andreas
Navarro, David
Canaro, Mariana
Güertler, Lutz
Ironside, James W.
author_facet Di Minno, Giovanni
Perno, Carlo Federico
Tiede, Andreas
Navarro, David
Canaro, Mariana
Güertler, Lutz
Ironside, James W.
author_sort Di Minno, Giovanni
collection PubMed
description The pathogen safety of blood/plasma-derived products has historically been a subject of significant concern to the medical community. Measures such as donor selection and blood screening have contributed to increase the safety of these products, but pathogen transmission does still occur. Reasons for this include lack of sensitivity/specificity of current screening methods, lack of reliable screening tests for some pathogens (e.g. prions) and the fact that many potentially harmful infectious agents are not routinely screened for. Methods for the purification/inactivation of blood/plasma-derived products have been developed in order to further reduce the residual risk, but low concentrations of pathogens do not necessarily imply a low level of risk for the patient and so the overall challenge of minimising risk remains. This review aims to discuss the variable level of pathogenic risk and describes the current screening methods used to prevent/detect the presence of pathogens in blood/plasma-derived products.
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spelling pubmed-71157162020-04-02 Current concepts in the prevention of pathogen transmission via blood/plasma-derived products for bleeding disorders() Di Minno, Giovanni Perno, Carlo Federico Tiede, Andreas Navarro, David Canaro, Mariana Güertler, Lutz Ironside, James W. Blood Rev Review The pathogen safety of blood/plasma-derived products has historically been a subject of significant concern to the medical community. Measures such as donor selection and blood screening have contributed to increase the safety of these products, but pathogen transmission does still occur. Reasons for this include lack of sensitivity/specificity of current screening methods, lack of reliable screening tests for some pathogens (e.g. prions) and the fact that many potentially harmful infectious agents are not routinely screened for. Methods for the purification/inactivation of blood/plasma-derived products have been developed in order to further reduce the residual risk, but low concentrations of pathogens do not necessarily imply a low level of risk for the patient and so the overall challenge of minimising risk remains. This review aims to discuss the variable level of pathogenic risk and describes the current screening methods used to prevent/detect the presence of pathogens in blood/plasma-derived products. Published by Elsevier Ltd. 2016-01 2015-07-20 /pmc/articles/PMC7115716/ /pubmed/26381318 http://dx.doi.org/10.1016/j.blre.2015.07.004 Text en Copyright © 2015 Published by Elsevier Ltd. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Review
Di Minno, Giovanni
Perno, Carlo Federico
Tiede, Andreas
Navarro, David
Canaro, Mariana
Güertler, Lutz
Ironside, James W.
Current concepts in the prevention of pathogen transmission via blood/plasma-derived products for bleeding disorders()
title Current concepts in the prevention of pathogen transmission via blood/plasma-derived products for bleeding disorders()
title_full Current concepts in the prevention of pathogen transmission via blood/plasma-derived products for bleeding disorders()
title_fullStr Current concepts in the prevention of pathogen transmission via blood/plasma-derived products for bleeding disorders()
title_full_unstemmed Current concepts in the prevention of pathogen transmission via blood/plasma-derived products for bleeding disorders()
title_short Current concepts in the prevention of pathogen transmission via blood/plasma-derived products for bleeding disorders()
title_sort current concepts in the prevention of pathogen transmission via blood/plasma-derived products for bleeding disorders()
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7115716/
https://www.ncbi.nlm.nih.gov/pubmed/26381318
http://dx.doi.org/10.1016/j.blre.2015.07.004
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