Covalent modification of phosphatidylethanolamine by 4-hydroxy-2-nonenal increases sodium permeability across phospholipid bilayer membranes

Reactive aldehydes (RAs), such as 4-hydroxy-2-nonenal (HNE) and 4-oxo-2-nonenal (ONE), produced by cells under conditions of oxidative stress, were shown to react with phosphatidylethanolamine (PE) in biological and artificial membranes. They form RA-PE adducts, which affect the function of membrane...

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Detalles Bibliográficos
Autores principales: Jovanović, Olga, Škulj, Sanja, Pohl, Elena E., Vazdar, Mario
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7115857/
https://www.ncbi.nlm.nih.gov/pubmed/31461663
http://dx.doi.org/10.1016/j.freeradbiomed.2019.08.027

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7115857/
https://www.ncbi.nlm.nih.gov/pubmed/31461663
http://dx.doi.org/10.1016/j.freeradbiomed.2019.08.027

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