Cargando…

The breast cancer oncogene IKKε coordinates mitochondrial function and serine metabolism

IκB kinase ε (IKKε) is a key molecule at the crossroads of inflammation and cancer. Known to regulate cytokine secretion via NFκB and IRF3, the kinase is also a breast cancer oncogene, overexpressed in a variety of tumours. However, to what extent IKKε remodels cellular metabolism is currently unkno...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xu, Ruoyan, Jones, William, Wilcz‐Villega, Ewa, Costa, Ana SH, Rajeeve, Vinothini, Bentham, Robert B, Bryson, Kevin, Nagano, Ai, Yaman, Busra, Olendo Barasa, Sheila, Wang, Yewei, Chelala, Claude, Cutillas, Pedro, Szabadkai, Gyorgy, Frezza, Christian, Bianchi, Katiuscia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2020
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7116048/ https://www.ncbi.nlm.nih.gov/pubmed/32783398 http://dx.doi.org/10.15252/embr.201948260

Ejemplares similares

Macrophages induce malignant traits in mammary epithelium via IKKε/TBK1 kinases and the serine biosynthesis pathway
por: Wilcz‐Villega, Ewa, et al.
Publicado: (2020)

Roles for the IKK-Related Kinases TBK1 and IKKε in Cancer
por: Durand, Joel K., et al.
Publicado: (2018)

MCbiclust: a novel algorithm to discover large-scale functionally related gene sets from massive transcriptomics data collections
por: Bentham, Robert B., et al.
Publicado: (2017)

IKKε and TBK1 expression in gastric cancer
por: Eun Lee, Seung, et al.
Publicado: (2016)

Withanolide Metabolites Inhibit PI3K/AKT and MAPK Pro-Survival Pathways and Induce Apoptosis in Acute Myeloid Leukemia Cells
por: Akhtar, Nosheen, et al.
Publicado: (2020)

Sequence and Structure-Based Analysis of Specificity Determinants in Eukaryotic Protein Kinases
por: Bradley, David, et al.
Publicado: (2021)

The cytotoxic action of BCI is not dependent on its stated DUSP1 or DUSP6 targets in neuroblastoma cells
por: Thompson, Elliott M., et al.
Publicado: (2022)

Role of IKKε in the Metabolic Diseases: Physiology, Pathophysiology, and Pharmacology
por: Xiao, Qing-Ao, et al.
Publicado: (2022)

Oxidative Stress in Cells with Extra Centrosomes Drives Non-Cell-Autonomous Invasion
por: Arnandis, Teresa, et al.
Publicado: (2018)

eEF2K Activity Determines Synergy to Cotreatment of Cancer Cells With PI3K and MEK Inhibitors
por: Hijazi, Maruan, et al.
Publicado: (2022)

IKKε inhibits PKC to promote Fascin-dependent actin bundling
por: Otani, Tetsuhisa, et al.
Publicado: (2016)

Targeting HER2(+) breast cancer: the TBK1/IKKε axis
por: Jiang, Zhe, et al.
Publicado: (2014)

Inhibition of TBK1/IKKε Promotes Regeneration of Pancreatic β-cells
por: Xu, Jin, et al.
Publicado: (2018)

The TBK1/IKKε inhibitor amlexanox improves dyslipidemia and prevents atherosclerosis
por: Zhao, Peng, et al.
Publicado: (2022)

IKKε and TBK1 in diffuse large B‐cell lymphoma: A possible mechanism of action of an IKKε/TBK1 inhibitor to repress NF‐κB and IL‐10 signalling
por: Carr, Matthew, et al.
Publicado: (2020)

LGG-57. SIGNALLING MECHANISMS IN PAEDIATRIC LOW-GRADE GLIOMA
por: Patel, Ankit, et al.
Publicado: (2020)

Computational Analysis of Cholangiocarcinoma Phosphoproteomes Identifies Patient-Specific Drug Targets
por: Khorsandi, Shirin Elizabeth, et al.
Publicado: (2021)

Development of a High-Throughput Assay for Identifying Inhibitors of TBK1 and IKKε
por: Hutti, Jessica E., et al.
Publicado: (2012)

PSMB1 Negatively Regulates the Innate Antiviral Immunity by Facilitating Degradation of IKK-ε
por: Wu, Fangyi, et al.
Publicado: (2019)

IKKε isoform switching governs the immune response against EV71 infection
por: Chang, Ya-Ling, et al.
Publicado: (2021)

The Nϵ‐Rule for Serine, but Not Cysteine Catalytic Triads
por: Czapinska, Honorata, et al.
Publicado: (2022)

Shedding of bevacizumab in tumour cells-derived extracellular vesicles as a new therapeutic escape mechanism in glioblastoma
por: Simon, Thomas, et al.
Publicado: (2018)

Silencing of the IKKε gene by siRNA inhibits invasiveness and growth of breast cancer cells
por: Qin, Bin, et al.
Publicado: (2010)

An inhibitor of the protein kinases TBK1/IKKε improves obesity-related metabolic dysfunctions
por: Reilly, Shannon M., et al.
Publicado: (2013)

Local and Systemic IKKε and NF-κB Signaling Associated with Sjögren's Syndrome Immunopathogenesis
por: Chen, Weiqian, et al.
Publicado: (2015)

MAVS activates TBK1 and IKKε through TRAFs in NEMO dependent and independent manner
por: Fang, Run, et al.
Publicado: (2017)

Microbial recognition by GEF-H1 controls IKKε mediated activation of IRF5
por: Zhao, Yun, et al.
Publicado: (2019)

TBK1 and IKKε prevent TNF-induced cell death by RIPK1 phosphorylation
por: Lafont, Elodie, et al.
Publicado: (2018)

IKKε deficiency inhibits acute lung injury following renal ischemia reperfusion injury
por: Meng, Chao, et al.
Publicado: (2020)

Publisher Correction: Inhibition of TBK1/IKKε Promotes Regeneration of Pancreatic β-cells
por: Xu, Jin, et al.
Publicado: (2019)

IKKε phosphorylates kindlin-2 to induce invadopodia formation and promote colorectal cancer metastasis
por: Liu, Ge, et al.
Publicado: (2020)

Targeting IKKε in Androgen-Independent Prostate Cancer Causes Phenotypic Senescence and Genomic Instability
por: Gilbert, Sophie, et al.
Publicado: (2022)

SPI-2/CrmA inhibits IFN-β induction by targeting TBK1/IKKε
por: Qin, Yue, et al.
Publicado: (2017)

Characterization of four subtypes in morphologically normal tissue excised proximal and distal to breast cancer
por: Gadaleta, Emanuela, et al.
Publicado: (2020)

Functionally Distinct Effects of the C-Terminal Regions of IKKε and TBK1 on Type I IFN Production
por: Nakatsu, Yuichiro, et al.
Publicado: (2014)

Detection of IKKε by immunohistochemistry in primary breast cancer: association with EGFR expression and absence of lymph node metastasis
por: Williams, Virginie, et al.
Publicado: (2017)

TBK1 and IKKε act like an OFF switch to limit NLRP3 inflammasome pathway activation
por: Fischer, Fabian A., et al.
Publicado: (2021)

Phosphorylation of RIPK1 serine 25 mediates IKK dependent control of extrinsic cell death in T cells
por: Blanchett, Sam, et al.
Publicado: (2022)

IKBKB reduces huntingtin aggregation by phosphorylating serine 13 via a non-canonical IKK pathway
por: Cariulo, Cristina, et al.
Publicado: (2023)

Specification of the NF-κB transcriptional response by p65 phosphorylation and TNF-induced nuclear translocation of IKKε
por: Moreno, Rita, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_94qdamufm1vis3nroqbg2sq77o