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Development of PROTACs to address clinical limitations associated with BTK-targeted kinase inhibitors

Chronic lymphocytic leukemia is a common form of leukemia and is dependent on growth-promoting signaling via the B-cell receptor. The Bruton tyrosine kinase (BTK) is an important mediator of B-cell receptor signaling and the irreversible BTK inhibitor ibrutinib can trigger dramatic clinical response...

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Detalles Bibliográficos
Autores principales:	Arthur, Rachael, Valle-Argos, Beatriz, Steele, Andrew J., Packham, Graham
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Open Exploration 2020
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7116064/ https://www.ncbi.nlm.nih.gov/pubmed/32924028 http://dx.doi.org/10.37349/etat.2020.00009

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