Cargando…

Nanobody-targeted photodynamic therapy induces significant tumor regression of trastuzumab-resistant HER2-positive breast cancer, after a single treatment session

RATIONALE: A substantial number of breast cancer patients with an overexpression of the human epidermal growth factor receptor 2 (HER2) have residual disease after neoadjuvant therapy or become resistant to trastuzumab. Photodynamic therapy (PDT) using nanobodies targeted to HER2 is a promising trea...

Descripción completa

Detalles Bibliográficos
Autores principales:	Deken, Marion M., Kijanka, Marta M., Hernández, Irati Beltrán, Slooter, Maxime D., de Bruijn, Henriette S., van Diest, Paul J., van Bergen en Henegouwen, Paul M.P., Lowik, Clemens W.G.M., Robinson, Dominic J., Vahrmeijer, Alexander L., Oliveira, Sabrina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7116241/ https://www.ncbi.nlm.nih.gov/pubmed/32330574 http://dx.doi.org/10.1016/j.jconrel.2020.04.030

Ejemplares similares

EGFR targeted nanobody–photosensitizer conjugates for photodynamic therapy in a pre-clinical model of head and neck cancer
por: van Driel, Pieter B.A.A., et al.
Publicado: (2016)

Acute cellular and vascular responses to photodynamic therapy using EGFR-targeted nanobody-photosensitizer conjugates studied with intravital optical imaging and magnetic resonance imaging
por: de Bruijn, Henriette S., et al.
Publicado: (2020)

Dual Targeting of Endothelial and Cancer Cells Potentiates In Vitro Nanobody-Targeted Photodynamic Therapy
por: Mashayekhi, Vida, et al.
Publicado: (2020)

Nanobody-targeted photodynamic therapy for the treatment of feline oral carcinoma: a step towards translation to the veterinary clinic
por: Beltrán Hernández, Irati, et al.
Publicado: (2021)

The Potential of Nanobody-Targeted Photodynamic Therapy to Trigger Immune Responses
por: Beltrán Hernández, Irati, et al.
Publicado: (2020)

Resolving bundled microtubules using anti-tubulin nanobodies
por: Mikhaylova, Marina, et al.
Publicado: (2015)

EGFR-Targeted Nanobody Functionalized Polymeric Micelles Loaded with mTHPC for Selective Photodynamic Therapy
por: Liu, Yanna, et al.
Publicado: (2020)

Optical imaging of pre-invasive breast cancer with a combination of VHHs targeting CAIX and HER2 increases contrast and facilitates tumour characterization
por: Kijanka, Marta M., et al.
Publicado: (2016)

Hypoxia-Targeting Fluorescent Nanobodies for Optical Molecular Imaging of Pre-Invasive Breast Cancer
por: van Brussel, Aram S. A., et al.
Publicado: (2015)

Structural insights into the non-inhibitory mechanism of the anti-EGFR EgB4 nanobody
por: Zeronian, Matthieu R., et al.
Publicado: (2022)

High affinity nanobodies against human epidermal growth factor receptor selected on cells by E. coli display
por: Salema, Valencio, et al.
Publicado: (2016)

VHH-Photosensitizer Conjugates for Targeted Photodynamic Therapy of Met-Overexpressing Tumor Cells
por: Heukers, Raimond, et al.
Publicado: (2019)

Probing cytoskeletal modulation of passive and active intracellular dynamics using nanobody-functionalized quantum dots
por: Katrukha, Eugene A., et al.
Publicado: (2017)

Eps15: a multifunctional adaptor protein regulating intracellular trafficking
por: van Bergen en Henegouwen, Paul MP
Publicado: (2009)

Development of in vitro-grown spheroids as a 3D tumor model system for solid-state NMR spectroscopy
por: Damman, Reinier, et al.
Publicado: (2020)

Homogeneous tumor targeting with a single dose of HER2-targeted albumin-binding domain-fused nanobody-drug conjugates results in long-lasting tumor remission in mice
por: Xenaki, Katerina T, et al.
Publicado: (2021)

Multifaceted Activities of Seven Nanobodies against Complement C4b
por: De la O Becerra, Karla I., et al.
Publicado: (2022)

Specific tumor targeting and activation of Vγ9Vδ2 T cells by bi-specific nanobodies
por: Stam, Anita, et al.
Publicado: (2014)

A Nanobody‐on‐Quantum Dot Displacement Assay for Rapid and Sensitive Quantification of the Epidermal Growth Factor Receptor (EGFR)
por: Su, Ruifang, et al.
Publicado: (2022)

Penetration of Nanobody-Dextran Polymer Conjugates through Tumor Spheroids
por: Bitsch, Peter, et al.
Publicado: (2023)

Facile labelling of an anti-epidermal growth factor receptor Nanobody with (68)Ga via a novel bifunctional desferal chelate for immuno-PET
por: Vosjan, Maria J. W. D., et al.
Publicado: (2011)

Multimodal image-guided surgery of HER2-positive breast cancer using [(111)In]In-DTPA-trastuzumab-IRDye800CW in an orthotopic breast tumor model
por: Deken, Marion M., et al.
Publicado: (2019)

A novel method to quantify IRDye800CW fluorescent antibody probes ex vivo in tissue distribution studies
por: Oliveira, Sabrina, et al.
Publicado: (2012)

Nanobody-Targeted Photodynamic Therapy Selectively Kills Viral GPCR-Expressing Glioblastoma Cells
por: De Groof, Timo W. M., et al.
Publicado: (2019)

Association and Colocalization of Eps15 with Adaptor Protein-2 and Clathrin
por: van Delft, Sanne, et al.
Publicado: (1997)

Oncologic Photodynamic Therapy: Basic Principles, Current Clinical Status and Future Directions
por: van Straten, Demian, et al.
Publicado: (2017)

Preclinical and Clinical Evidence of Immune Responses Triggered in Oncologic Photodynamic Therapy: Clinical Recommendations
por: Beltrán Hernández, Irati, et al.
Publicado: (2020)

Concurrent versus sequential use of trastuzumab and chemotherapy in early HER2+ breast cancer
por: Dackus, Gwen M. H. E., et al.
Publicado: (2020)

ADAM10-mediated release of heregulin confers resistance to trastuzumab by activating HER3
por: Ebbing, Eva A., et al.
Publicado: (2016)

Membrane domain formation—a key factor for targeted intracellular drug delivery
por: Popov-Čeleketić, Dušan, et al.
Publicado: (2014)

Targeted nanobody complex enhanced photodynamic therapy for lung cancer by overcoming tumor microenvironment
por: Zhang, Qing, et al.
Publicado: (2020)

Somatostatin Analogues for Receptor Targeted Photodynamic Therapy
por: Kaščáková, Slávka, et al.
Publicado: (2014)

Antibody or Antibody Fragments: Implications for Molecular Imaging and Targeted Therapy of Solid Tumors
por: Xenaki, Katerina T., et al.
Publicado: (2017)

Light Fractionation Significantly Increases the Efficacy of Photodynamic Therapy Using BF-200 ALA in Normal Mouse Skin
por: de Bruijn, Henriëtte S., et al.
Publicado: (2016)

SINGLE-SESSION BILATERAL REDUCED-SETTINGS PHOTODYNAMIC THERAPY FOR BILATERAL CHRONIC CENTRAL SEROUS CHORIORETINOPATHY
por: Pauleikhoff, Laurenz J.B., et al.
Publicado: (2023)

Patient-Derived Head and Neck Cancer Organoids Recapitulate EGFR Expression Levels of Respective Tissues and Are Responsive to EGFR-Targeted Photodynamic Therapy
por: Driehuis, Else, et al.
Publicado: (2019)

ErbB1 dimerization is promoted by domain co-confinement and stabilized by ligand-binding
por: Low-Nam, Shalini T., et al.
Publicado: (2011)

(89)Zr-Trastuzumab PET/CT Imaging of HER2-Positive Breast Cancer for Predicting Pathological Complete Response after Neoadjuvant Systemic Therapy: A Feasibility Study
por: Linders, D. G. J., et al.
Publicado: (2023)

In-Vivo Optical Monitoring of the Efficacy of Epidermal Growth Factor Receptor Targeted Photodynamic Therapy: The Effect of Fluence Rate
por: Peng, Wei, et al.
Publicado: (2020)

Recombinant expression of nanobodies and nanobody-derived immunoreagents
por: de Marco, Ario
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_n1mna8277pckodbvb3m5l7nvab