Mitochondrial Dysfunction Accelerates Ageing

We review here the seminal findings of Desdin-Mico et al. showing that T cells with dysfunctional mitochondria induce multimorbity and premature senescence, due to mitochondrial transcription factor A (TFAM). They add further weight to the idea that targeting immunometabolism could be beneficial in...

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Detalles Bibliográficos
Autores principales: Schroth, Johannes, Henson, Sian M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7116259/
https://www.ncbi.nlm.nih.gov/pubmed/33101729
http://dx.doi.org/10.20900/immunometab20200035
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author Schroth, Johannes
Henson, Sian M.
author_facet Schroth, Johannes
Henson, Sian M.
author_sort Schroth, Johannes
collection PubMed
description We review here the seminal findings of Desdin-Mico et al. showing that T cells with dysfunctional mitochondria induce multimorbity and premature senescence, due to mitochondrial transcription factor A (TFAM). They add further weight to the idea that targeting immunometabolism could be beneficial in combating the detrimental effects of age-related disease.
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spelling pubmed-71162592020-10-24 Mitochondrial Dysfunction Accelerates Ageing Schroth, Johannes Henson, Sian M. Immunometabolism Article We review here the seminal findings of Desdin-Mico et al. showing that T cells with dysfunctional mitochondria induce multimorbity and premature senescence, due to mitochondrial transcription factor A (TFAM). They add further weight to the idea that targeting immunometabolism could be beneficial in combating the detrimental effects of age-related disease. 2020-10-16 /pmc/articles/PMC7116259/ /pubmed/33101729 http://dx.doi.org/10.20900/immunometab20200035 Text en https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms and conditions of Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Schroth, Johannes
Henson, Sian M.
Mitochondrial Dysfunction Accelerates Ageing
title Mitochondrial Dysfunction Accelerates Ageing
title_full Mitochondrial Dysfunction Accelerates Ageing
title_fullStr Mitochondrial Dysfunction Accelerates Ageing
title_full_unstemmed Mitochondrial Dysfunction Accelerates Ageing
title_short Mitochondrial Dysfunction Accelerates Ageing
title_sort mitochondrial dysfunction accelerates ageing
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7116259/
https://www.ncbi.nlm.nih.gov/pubmed/33101729
http://dx.doi.org/10.20900/immunometab20200035
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AT hensonsianm mitochondrialdysfunctionacceleratesageing

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