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Neural inhibition for continual learning and memory

Humans are able to continually learn new information and acquire skills that meet the demands of an ever-changing environment. Yet, this new learning does not necessarily occur at the expense of old memories. The specialised biological mechanisms that permit continual learning in humans and other ma...

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Detalles Bibliográficos
Autor principal: Barron, Helen C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Current Biology 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7116367/
https://www.ncbi.nlm.nih.gov/pubmed/33129012
http://dx.doi.org/10.1016/j.conb.2020.09.007
Descripción
Sumario:Humans are able to continually learn new information and acquire skills that meet the demands of an ever-changing environment. Yet, this new learning does not necessarily occur at the expense of old memories. The specialised biological mechanisms that permit continual learning in humans and other mammals are not fully understood. Here I explore the possibility that neural inhibition plays an important role. I present recent findings from studies in humans that suggest inhibition regulates the stability of neural networks to gate cortical plasticity and memory retrieval. These studies use non-invasive methods to obtain an indirect measure of neural inhibition and corroborate comparable findings in animals. Together these studies reveal a model whereby neural inhibition protects memories from interference to permit continual learning. Neural inhibition may, therefore, play a critical role in the computations that underlie higher-order cognition and adaptive behaviour.