Orai channels: key players in Ca(2+) homeostasis

Maintaining a precise calcium (Ca(2+)) balance is vital for cellular survival. The most prominent pathway to shuttle Ca(2+) into cells is the Ca(2+) release activated Ca(2+) (CRAC) channel. Orai proteins are indispensable players in this central mechanism of Ca(2+) entry. This short review traces th...

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Detalles Bibliográficos
Autores principales: Sallinger, Matthias, Berlansky, Sascha, Frischauf, Irene
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7116546/
https://www.ncbi.nlm.nih.gov/pubmed/33409426
http://dx.doi.org/10.1016/j.cophys.2020.06.006
Descripción
Sumario:Maintaining a precise calcium (Ca(2+)) balance is vital for cellular survival. The most prominent pathway to shuttle Ca(2+) into cells is the Ca(2+) release activated Ca(2+) (CRAC) channel. Orai proteins are indispensable players in this central mechanism of Ca(2+) entry. This short review traces the latest articles published in the field of CRAC channel signalling with a focus on the structure of the pore-forming Orai proteins, the propagation of the binding signal from STIM1 through the channel to the central pore and their role in human health and disease.

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