Orai channels: key players in Ca(2+) homeostasis

Maintaining a precise calcium (Ca(2+)) balance is vital for cellular survival. The most prominent pathway to shuttle Ca(2+) into cells is the Ca(2+) release activated Ca(2+) (CRAC) channel. Orai proteins are indispensable players in this central mechanism of Ca(2+) entry. This short review traces th...

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Detalles Bibliográficos
Autores principales: Sallinger, Matthias, Berlansky, Sascha, Frischauf, Irene
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7116546/
https://www.ncbi.nlm.nih.gov/pubmed/33409426
http://dx.doi.org/10.1016/j.cophys.2020.06.006
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author Sallinger, Matthias
Berlansky, Sascha
Frischauf, Irene
author_facet Sallinger, Matthias
Berlansky, Sascha
Frischauf, Irene
author_sort Sallinger, Matthias
collection PubMed
description Maintaining a precise calcium (Ca(2+)) balance is vital for cellular survival. The most prominent pathway to shuttle Ca(2+) into cells is the Ca(2+) release activated Ca(2+) (CRAC) channel. Orai proteins are indispensable players in this central mechanism of Ca(2+) entry. This short review traces the latest articles published in the field of CRAC channel signalling with a focus on the structure of the pore-forming Orai proteins, the propagation of the binding signal from STIM1 through the channel to the central pore and their role in human health and disease.
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spelling pubmed-71165462021-01-05 Orai channels: key players in Ca(2+) homeostasis Sallinger, Matthias Berlansky, Sascha Frischauf, Irene Curr Opin Physiol Article Maintaining a precise calcium (Ca(2+)) balance is vital for cellular survival. The most prominent pathway to shuttle Ca(2+) into cells is the Ca(2+) release activated Ca(2+) (CRAC) channel. Orai proteins are indispensable players in this central mechanism of Ca(2+) entry. This short review traces the latest articles published in the field of CRAC channel signalling with a focus on the structure of the pore-forming Orai proteins, the propagation of the binding signal from STIM1 through the channel to the central pore and their role in human health and disease. 2020-10 2020-06-29 /pmc/articles/PMC7116546/ /pubmed/33409426 http://dx.doi.org/10.1016/j.cophys.2020.06.006 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Sallinger, Matthias
Berlansky, Sascha
Frischauf, Irene
Orai channels: key players in Ca(2+) homeostasis
title Orai channels: key players in Ca(2+) homeostasis
title_full Orai channels: key players in Ca(2+) homeostasis
title_fullStr Orai channels: key players in Ca(2+) homeostasis
title_full_unstemmed Orai channels: key players in Ca(2+) homeostasis
title_short Orai channels: key players in Ca(2+) homeostasis
title_sort orai channels: key players in ca(2+) homeostasis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7116546/
https://www.ncbi.nlm.nih.gov/pubmed/33409426
http://dx.doi.org/10.1016/j.cophys.2020.06.006
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