Effective drug treatment identified by in vivo screening in a transplantable patient-derived xenograft model of chronic myelomonocytic leukemia

To establish novel and effective treatment combinations for chronic myelomonocytic leukemia (CMML) preclinically, we hypothesized that supplementation of CMML cells with the human oncogene Meningioma 1 (MN1) promotes expansion and serial transplantability in mice, while maintaining the functional de...

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Detalles Bibliográficos
Autores principales: Kloos, Arnold, Mintzas, Konstantinos, Winckler, Lina, Gabdoulline, Razif, Alwie, Yasmine, Jyotsana, Nidhi, Kattre, Nadine, Schottmann, Renate, Scherr, Michaela, Gupta, Charu, Adams, Felix F., Schwarzer, Adrian, Heckl, Dirk, Schambach, Axel, Imren, Suzan, Humphries, R. Keith, Ganser, Arnold, Thol, Felicitas, Heuser, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7116758/
https://www.ncbi.nlm.nih.gov/pubmed/32576961
http://dx.doi.org/10.1038/s41375-020-0929-3

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