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A complex resistance locus in Solanum americanum recognizes a conserved Phytophthora effector
Late blight caused by Phytophthora infestans greatly constrains potato production. Many Resistance (R) genes were cloned from wild Solanum species and/or introduced into potato cultivars by breeding. However, individual R genes have been overcome by P. infestans evolution; durable resistance remains...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7116783/ https://www.ncbi.nlm.nih.gov/pubmed/33574576 http://dx.doi.org/10.1038/s41477-021-00854-9 |
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| author | Witek, Kamil Lin, Xiao Karki, Hari S Jupe, Florian Witek, Agnieszka I Steuernagel, Burkhard Stam, Remco van Oosterhout, Cock Fairhead, Sebastian Heal, Robert Cocker, Jonathan M Bhanvadia, Shivani Barrett, William Wu, Chih-Hang Adachi, Hiroaki Song, Tianqiao Kamoun, Sophien Vleeshouwers, Vivianne GAA Tomlinson, Laurence Wulff, Brande BH Jones, Jonathan DG |
| author_facet | Witek, Kamil Lin, Xiao Karki, Hari S Jupe, Florian Witek, Agnieszka I Steuernagel, Burkhard Stam, Remco van Oosterhout, Cock Fairhead, Sebastian Heal, Robert Cocker, Jonathan M Bhanvadia, Shivani Barrett, William Wu, Chih-Hang Adachi, Hiroaki Song, Tianqiao Kamoun, Sophien Vleeshouwers, Vivianne GAA Tomlinson, Laurence Wulff, Brande BH Jones, Jonathan DG |
| author_sort | Witek, Kamil |
| collection | PubMed |
| description | Late blight caused by Phytophthora infestans greatly constrains potato production. Many Resistance (R) genes were cloned from wild Solanum species and/or introduced into potato cultivars by breeding. However, individual R genes have been overcome by P. infestans evolution; durable resistance remains elusive. We positionally cloned a new R gene, Rpi-amr1, from Solanum americanum, that encodes an NRC helper-dependent CC-NLR protein.Rpi-amr1 confers resistance in potato to all 19 P. infestans isolates tested. Using association genomics and long-read RenSeq, we defined eight additional Rpi-amr1 alleles from different S. americanum and related species.Despite only ~90% identity between Rpi-amr1 proteins, all confer late blight resistance but differentially recognize Avramr1 orthologs and paralogs. We propose that Rpi-amr1 gene family diversity assists detection of diverse paralogs and alleles of the recognized effector, facilitating durable resistance against P. infestans. |
| format | Online Article Text |
| id | pubmed-7116783 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2021 |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-71167832021-08-11 A complex resistance locus in Solanum americanum recognizes a conserved Phytophthora effector Witek, Kamil Lin, Xiao Karki, Hari S Jupe, Florian Witek, Agnieszka I Steuernagel, Burkhard Stam, Remco van Oosterhout, Cock Fairhead, Sebastian Heal, Robert Cocker, Jonathan M Bhanvadia, Shivani Barrett, William Wu, Chih-Hang Adachi, Hiroaki Song, Tianqiao Kamoun, Sophien Vleeshouwers, Vivianne GAA Tomlinson, Laurence Wulff, Brande BH Jones, Jonathan DG Nat Plants Article Late blight caused by Phytophthora infestans greatly constrains potato production. Many Resistance (R) genes were cloned from wild Solanum species and/or introduced into potato cultivars by breeding. However, individual R genes have been overcome by P. infestans evolution; durable resistance remains elusive. We positionally cloned a new R gene, Rpi-amr1, from Solanum americanum, that encodes an NRC helper-dependent CC-NLR protein.Rpi-amr1 confers resistance in potato to all 19 P. infestans isolates tested. Using association genomics and long-read RenSeq, we defined eight additional Rpi-amr1 alleles from different S. americanum and related species.Despite only ~90% identity between Rpi-amr1 proteins, all confer late blight resistance but differentially recognize Avramr1 orthologs and paralogs. We propose that Rpi-amr1 gene family diversity assists detection of diverse paralogs and alleles of the recognized effector, facilitating durable resistance against P. infestans. 2021-02-01 2021-02-11 /pmc/articles/PMC7116783/ /pubmed/33574576 http://dx.doi.org/10.1038/s41477-021-00854-9 Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms |
| spellingShingle | Article Witek, Kamil Lin, Xiao Karki, Hari S Jupe, Florian Witek, Agnieszka I Steuernagel, Burkhard Stam, Remco van Oosterhout, Cock Fairhead, Sebastian Heal, Robert Cocker, Jonathan M Bhanvadia, Shivani Barrett, William Wu, Chih-Hang Adachi, Hiroaki Song, Tianqiao Kamoun, Sophien Vleeshouwers, Vivianne GAA Tomlinson, Laurence Wulff, Brande BH Jones, Jonathan DG A complex resistance locus in Solanum americanum recognizes a conserved Phytophthora effector |
| title | A complex resistance locus in Solanum americanum recognizes a conserved Phytophthora effector |
| title_full | A complex resistance locus in Solanum americanum recognizes a conserved Phytophthora effector |
| title_fullStr | A complex resistance locus in Solanum americanum recognizes a conserved Phytophthora effector |
| title_full_unstemmed | A complex resistance locus in Solanum americanum recognizes a conserved Phytophthora effector |
| title_short | A complex resistance locus in Solanum americanum recognizes a conserved Phytophthora effector |
| title_sort | complex resistance locus in solanum americanum recognizes a conserved phytophthora effector |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7116783/ https://www.ncbi.nlm.nih.gov/pubmed/33574576 http://dx.doi.org/10.1038/s41477-021-00854-9 |
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