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Synthesis of enantiomerically pure alcohols and amines via biocatalytic deracemisation methods
Deracemisation via chemo-enzymatic or multi-enzymatic approaches is the optimum substitute for kinetic resolution, which suffers from the limitation of a theoretical maximum 50% yield albeit high enantiomeric excess is attainable. This review covers the recent progress in various deracemisation appr...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7116805/ https://www.ncbi.nlm.nih.gov/pubmed/33628427 http://dx.doi.org/10.1039/C9CY01539F |
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author | Musa, Musa M. Hollmann, Frank Mutti, Francesco G. |
author_facet | Musa, Musa M. Hollmann, Frank Mutti, Francesco G. |
author_sort | Musa, Musa M. |
collection | PubMed |
description | Deracemisation via chemo-enzymatic or multi-enzymatic approaches is the optimum substitute for kinetic resolution, which suffers from the limitation of a theoretical maximum 50% yield albeit high enantiomeric excess is attainable. This review covers the recent progress in various deracemisation approaches applied to the synthesis of enantiomerically pure alcohols and amines, such as (1) dynamic kinetic resolution, (2) cyclic deracemisation, (3) linear deracemisation (including stereoinversion) and (4) enantioconvergent methods. |
format | Online Article Text |
id | pubmed-7116805 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
record_format | MEDLINE/PubMed |
spelling | pubmed-71168052021-02-23 Synthesis of enantiomerically pure alcohols and amines via biocatalytic deracemisation methods Musa, Musa M. Hollmann, Frank Mutti, Francesco G. Catal Sci Technol Article Deracemisation via chemo-enzymatic or multi-enzymatic approaches is the optimum substitute for kinetic resolution, which suffers from the limitation of a theoretical maximum 50% yield albeit high enantiomeric excess is attainable. This review covers the recent progress in various deracemisation approaches applied to the synthesis of enantiomerically pure alcohols and amines, such as (1) dynamic kinetic resolution, (2) cyclic deracemisation, (3) linear deracemisation (including stereoinversion) and (4) enantioconvergent methods. 2019-10-21 2019-09-03 /pmc/articles/PMC7116805/ /pubmed/33628427 http://dx.doi.org/10.1039/C9CY01539F Text en https://creativecommons.org/licenses/by/3.0/ This article is licensed under a Creative Commons Attribution 3.0 Unported Licence (https://creativecommons.org/licenses/by/3.0/) . |
spellingShingle | Article Musa, Musa M. Hollmann, Frank Mutti, Francesco G. Synthesis of enantiomerically pure alcohols and amines via biocatalytic deracemisation methods |
title | Synthesis of enantiomerically pure alcohols and amines via biocatalytic deracemisation methods |
title_full | Synthesis of enantiomerically pure alcohols and amines via biocatalytic deracemisation methods |
title_fullStr | Synthesis of enantiomerically pure alcohols and amines via biocatalytic deracemisation methods |
title_full_unstemmed | Synthesis of enantiomerically pure alcohols and amines via biocatalytic deracemisation methods |
title_short | Synthesis of enantiomerically pure alcohols and amines via biocatalytic deracemisation methods |
title_sort | synthesis of enantiomerically pure alcohols and amines via biocatalytic deracemisation methods |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7116805/ https://www.ncbi.nlm.nih.gov/pubmed/33628427 http://dx.doi.org/10.1039/C9CY01539F |
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