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Synthesis of enantiomerically pure alcohols and amines via biocatalytic deracemisation methods

Deracemisation via chemo-enzymatic or multi-enzymatic approaches is the optimum substitute for kinetic resolution, which suffers from the limitation of a theoretical maximum 50% yield albeit high enantiomeric excess is attainable. This review covers the recent progress in various deracemisation appr...

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Detalles Bibliográficos
Autores principales: Musa, Musa M., Hollmann, Frank, Mutti, Francesco G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7116805/
https://www.ncbi.nlm.nih.gov/pubmed/33628427
http://dx.doi.org/10.1039/C9CY01539F
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author Musa, Musa M.
Hollmann, Frank
Mutti, Francesco G.
author_facet Musa, Musa M.
Hollmann, Frank
Mutti, Francesco G.
author_sort Musa, Musa M.
collection PubMed
description Deracemisation via chemo-enzymatic or multi-enzymatic approaches is the optimum substitute for kinetic resolution, which suffers from the limitation of a theoretical maximum 50% yield albeit high enantiomeric excess is attainable. This review covers the recent progress in various deracemisation approaches applied to the synthesis of enantiomerically pure alcohols and amines, such as (1) dynamic kinetic resolution, (2) cyclic deracemisation, (3) linear deracemisation (including stereoinversion) and (4) enantioconvergent methods.
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spelling pubmed-71168052021-02-23 Synthesis of enantiomerically pure alcohols and amines via biocatalytic deracemisation methods Musa, Musa M. Hollmann, Frank Mutti, Francesco G. Catal Sci Technol Article Deracemisation via chemo-enzymatic or multi-enzymatic approaches is the optimum substitute for kinetic resolution, which suffers from the limitation of a theoretical maximum 50% yield albeit high enantiomeric excess is attainable. This review covers the recent progress in various deracemisation approaches applied to the synthesis of enantiomerically pure alcohols and amines, such as (1) dynamic kinetic resolution, (2) cyclic deracemisation, (3) linear deracemisation (including stereoinversion) and (4) enantioconvergent methods. 2019-10-21 2019-09-03 /pmc/articles/PMC7116805/ /pubmed/33628427 http://dx.doi.org/10.1039/C9CY01539F Text en https://creativecommons.org/licenses/by/3.0/ This article is licensed under a Creative Commons Attribution 3.0 Unported Licence (https://creativecommons.org/licenses/by/3.0/) .
spellingShingle Article
Musa, Musa M.
Hollmann, Frank
Mutti, Francesco G.
Synthesis of enantiomerically pure alcohols and amines via biocatalytic deracemisation methods
title Synthesis of enantiomerically pure alcohols and amines via biocatalytic deracemisation methods
title_full Synthesis of enantiomerically pure alcohols and amines via biocatalytic deracemisation methods
title_fullStr Synthesis of enantiomerically pure alcohols and amines via biocatalytic deracemisation methods
title_full_unstemmed Synthesis of enantiomerically pure alcohols and amines via biocatalytic deracemisation methods
title_short Synthesis of enantiomerically pure alcohols and amines via biocatalytic deracemisation methods
title_sort synthesis of enantiomerically pure alcohols and amines via biocatalytic deracemisation methods
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7116805/
https://www.ncbi.nlm.nih.gov/pubmed/33628427
http://dx.doi.org/10.1039/C9CY01539F
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