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Structure of Trypanosome Coat Protein VSGsur and Function in Suramin Resistance
Suramin has been a primary early-stage treatment for African trypanosomiasis for nearly one hundred years. Recent studies revealed that trypanosome strains that express the Variant Surface Glycoprotein VSGsur possess heightened resistance to suramin. We show here that VSGsur binds tightly to suramin...
| Autores principales: | , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7116837/ https://www.ncbi.nlm.nih.gov/pubmed/33462435 http://dx.doi.org/10.1038/s41564-020-00844-1 |