RORα is a critical checkpoint for T cell and ILC2 commitment in the embryonic thymus

Type 2 innate lymphoid cells (ILC2) contribute to immune homeostasis, protective immunity and tissue repair. Here we demonstrate that functional ILC2 can arise in the embryonic thymus, from shared T cell precursors, preceding the emergence of CD4(+)CD8(+) (double-positive) T cells. Thymic ILC2 migra...

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Detalles Bibliográficos
Autores principales: Ferreira, Ana C. F., Szeto, Aydan C. H., Heycock, Morgan W. D., Clark, Paula A., Walker, Jennifer A., Crisp, Alastair, Barlow, Jillian L., Kitching, Sophie, Lim, Alfred, Gogoi, Mayuri, Berks, Richard, Daly, Maria, Jolin, Helen E., McKenzie, Andrew N. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7116838/
https://www.ncbi.nlm.nih.gov/pubmed/33432227
http://dx.doi.org/10.1038/s41590-020-00833-w

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