A CD22-Shp1 phosphatase axis controls integrin β(7) display and B cell function in mucosal immunity

The integrin α(4)β(7) selectively regulates lymphocyte trafficking and adhesion in the gut and gut-associated lymphoid tissues (GALT). Here we describe unexpected involvement of tyrosine phosphatase Shp1 and the B cell lectin CD22 (Siglec 2) in regulation of α(4)β(7) surface expression and gut immun...

Descripción completa

Detalles Bibliográficos
Autores principales: Ballet, Romain, Brennan, Martin, Brandl, Carolin, Feng, Ningguo, Berri, Jeremy, Cheng, Julian, Ocón, Borja, Sheikh, Amin Alborzian Deh, Marki, Alex, Bi, Yuhan, Abram, Clare L., Lowell, Clifford A., Tsubata, Takeshi, Greenberg, Harry B., Macauley, Matthew S., Ley, Klaus, Nitschke, Lars, Butcher, Eugene C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7116842/
https://www.ncbi.nlm.nih.gov/pubmed/33589816
http://dx.doi.org/10.1038/s41590-021-00862-z

Ejemplares similares

Ejemplares similares