Integrating new memories into the hippocampal network activity space

By investigating the topology of neuronal coactivity, we found that mnemonic information spans multiple operational axes in the mouse hippocampus network. High activity principal cells form the core of each memory along a first axis, segregating spatial contexts and novelty. Low activity cells join...

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Detalles Bibliográficos
Autores principales: Gava, Giuseppe P., McHugh, Stephen B., Lefèvre, Laura, Lopes-dos-Santos, Vítor, Trouche, Stéphanie, El-Gaby, Mohamady, Schultz, Simon R., Dupret, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7116855/
https://www.ncbi.nlm.nih.gov/pubmed/33603228
http://dx.doi.org/10.1038/s41593-021-00804-w
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author Gava, Giuseppe P.
McHugh, Stephen B.
Lefèvre, Laura
Lopes-dos-Santos, Vítor
Trouche, Stéphanie
El-Gaby, Mohamady
Schultz, Simon R.
Dupret, David
author_facet Gava, Giuseppe P.
McHugh, Stephen B.
Lefèvre, Laura
Lopes-dos-Santos, Vítor
Trouche, Stéphanie
El-Gaby, Mohamady
Schultz, Simon R.
Dupret, David
author_sort Gava, Giuseppe P.
collection PubMed
description By investigating the topology of neuronal coactivity, we found that mnemonic information spans multiple operational axes in the mouse hippocampus network. High activity principal cells form the core of each memory along a first axis, segregating spatial contexts and novelty. Low activity cells join coactivity motifs across behavioural events and enable their crosstalk along two other axes. This reveals an organizational principle for continuous integration and interaction of hippocampal memories.
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spelling pubmed-71168552021-03-04 Integrating new memories into the hippocampal network activity space Gava, Giuseppe P. McHugh, Stephen B. Lefèvre, Laura Lopes-dos-Santos, Vítor Trouche, Stéphanie El-Gaby, Mohamady Schultz, Simon R. Dupret, David Nat Neurosci Article By investigating the topology of neuronal coactivity, we found that mnemonic information spans multiple operational axes in the mouse hippocampus network. High activity principal cells form the core of each memory along a first axis, segregating spatial contexts and novelty. Low activity cells join coactivity motifs across behavioural events and enable their crosstalk along two other axes. This reveals an organizational principle for continuous integration and interaction of hippocampal memories. 2021-03-01 2021-02-18 /pmc/articles/PMC7116855/ /pubmed/33603228 http://dx.doi.org/10.1038/s41593-021-00804-w Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Gava, Giuseppe P.
McHugh, Stephen B.
Lefèvre, Laura
Lopes-dos-Santos, Vítor
Trouche, Stéphanie
El-Gaby, Mohamady
Schultz, Simon R.
Dupret, David
Integrating new memories into the hippocampal network activity space
title Integrating new memories into the hippocampal network activity space
title_full Integrating new memories into the hippocampal network activity space
title_fullStr Integrating new memories into the hippocampal network activity space
title_full_unstemmed Integrating new memories into the hippocampal network activity space
title_short Integrating new memories into the hippocampal network activity space
title_sort integrating new memories into the hippocampal network activity space
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7116855/
https://www.ncbi.nlm.nih.gov/pubmed/33603228
http://dx.doi.org/10.1038/s41593-021-00804-w
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