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Association of COVID-19 inflammation with activation of the C5a-C5aR1 axis

Coronavirus disease 2019 (COVID-19) is a new pandemic disease caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The C5a anaphylatoxin and its receptor C5aR1 (CD88) play a key role in the initiation and maintenance of several inflammatory responses, by recruiting...

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Autores principales: Carvelli, Julien, Demaria, Olivier, Vély, Frédéric, Batista, Luciana, Benmansour, Nassima Chouaki, Fares, Joanna, Carpentier, Sabrina, Thibult, Marie-Laure, Morel, Ariane, Remark, Romain, André, Pascale, Represa, Agnès, Piperoglou, Christelle, Cordier, Pierre Yves, Le Dault, Erwan, Guervilly, Christophe, Simeone, Pierre, Gainnier, Marc, Morel, Yannis, Ebbo, Mikael, Schleinitz, Nicolas, Vivier, Eric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7116884/
https://www.ncbi.nlm.nih.gov/pubmed/32726800
http://dx.doi.org/10.1038/s41586-020-2600-6
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author Carvelli, Julien
Demaria, Olivier
Vély, Frédéric
Batista, Luciana
Benmansour, Nassima Chouaki
Fares, Joanna
Carpentier, Sabrina
Thibult, Marie-Laure
Morel, Ariane
Remark, Romain
André, Pascale
Represa, Agnès
Piperoglou, Christelle
Cordier, Pierre Yves
Le Dault, Erwan
Guervilly, Christophe
Simeone, Pierre
Gainnier, Marc
Morel, Yannis
Ebbo, Mikael
Schleinitz, Nicolas
Vivier, Eric
author_facet Carvelli, Julien
Demaria, Olivier
Vély, Frédéric
Batista, Luciana
Benmansour, Nassima Chouaki
Fares, Joanna
Carpentier, Sabrina
Thibult, Marie-Laure
Morel, Ariane
Remark, Romain
André, Pascale
Represa, Agnès
Piperoglou, Christelle
Cordier, Pierre Yves
Le Dault, Erwan
Guervilly, Christophe
Simeone, Pierre
Gainnier, Marc
Morel, Yannis
Ebbo, Mikael
Schleinitz, Nicolas
Vivier, Eric
author_sort Carvelli, Julien
collection PubMed
description Coronavirus disease 2019 (COVID-19) is a new pandemic disease caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The C5a anaphylatoxin and its receptor C5aR1 (CD88) play a key role in the initiation and maintenance of several inflammatory responses, by recruiting and activating neutrophils and monocytes in the lungs(1). We provide a longitudinal analysis of immune responses, including immune cell phenotyping and assessments of the soluble factors present in the blood and broncho-alveolar lavage fluid (BALF) of patients at various stages of COVID-19 severity: paucisymptomatic, pneumonia and acute respiratory distress syndrome (ARDS). We report an increase in soluble C5a levels proportional to COVID-19 severity and high levels of C5aR1 expression in blood and pulmonary myeloid cells, supporting a role for the C5a-C5aR1 axis in the pathophysiology of ARDS. Anti-C5aR1 therapeutic monoclonal antibodies (mAbs) prevented C5a-mediated human myeloid cell recruitment and activation, and inhibited acute lung injury (ALI) in human C5aR1 knockin mice. These results suggest that C5a-C5aR1 axis blockade might be used as a means of limiting myeloid cell infiltration in damaged organs and preventing the excessive lung inflammation and endothelialitis associated with ARDS in COVID-19 patients.
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spelling pubmed-71168842021-03-10 Association of COVID-19 inflammation with activation of the C5a-C5aR1 axis Carvelli, Julien Demaria, Olivier Vély, Frédéric Batista, Luciana Benmansour, Nassima Chouaki Fares, Joanna Carpentier, Sabrina Thibult, Marie-Laure Morel, Ariane Remark, Romain André, Pascale Represa, Agnès Piperoglou, Christelle Cordier, Pierre Yves Le Dault, Erwan Guervilly, Christophe Simeone, Pierre Gainnier, Marc Morel, Yannis Ebbo, Mikael Schleinitz, Nicolas Vivier, Eric Nature Article Coronavirus disease 2019 (COVID-19) is a new pandemic disease caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The C5a anaphylatoxin and its receptor C5aR1 (CD88) play a key role in the initiation and maintenance of several inflammatory responses, by recruiting and activating neutrophils and monocytes in the lungs(1). We provide a longitudinal analysis of immune responses, including immune cell phenotyping and assessments of the soluble factors present in the blood and broncho-alveolar lavage fluid (BALF) of patients at various stages of COVID-19 severity: paucisymptomatic, pneumonia and acute respiratory distress syndrome (ARDS). We report an increase in soluble C5a levels proportional to COVID-19 severity and high levels of C5aR1 expression in blood and pulmonary myeloid cells, supporting a role for the C5a-C5aR1 axis in the pathophysiology of ARDS. Anti-C5aR1 therapeutic monoclonal antibodies (mAbs) prevented C5a-mediated human myeloid cell recruitment and activation, and inhibited acute lung injury (ALI) in human C5aR1 knockin mice. These results suggest that C5a-C5aR1 axis blockade might be used as a means of limiting myeloid cell infiltration in damaged organs and preventing the excessive lung inflammation and endothelialitis associated with ARDS in COVID-19 patients. 2020-12-01 2020-07-29 /pmc/articles/PMC7116884/ /pubmed/32726800 http://dx.doi.org/10.1038/s41586-020-2600-6 Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Carvelli, Julien
Demaria, Olivier
Vély, Frédéric
Batista, Luciana
Benmansour, Nassima Chouaki
Fares, Joanna
Carpentier, Sabrina
Thibult, Marie-Laure
Morel, Ariane
Remark, Romain
André, Pascale
Represa, Agnès
Piperoglou, Christelle
Cordier, Pierre Yves
Le Dault, Erwan
Guervilly, Christophe
Simeone, Pierre
Gainnier, Marc
Morel, Yannis
Ebbo, Mikael
Schleinitz, Nicolas
Vivier, Eric
Association of COVID-19 inflammation with activation of the C5a-C5aR1 axis
title Association of COVID-19 inflammation with activation of the C5a-C5aR1 axis
title_full Association of COVID-19 inflammation with activation of the C5a-C5aR1 axis
title_fullStr Association of COVID-19 inflammation with activation of the C5a-C5aR1 axis
title_full_unstemmed Association of COVID-19 inflammation with activation of the C5a-C5aR1 axis
title_short Association of COVID-19 inflammation with activation of the C5a-C5aR1 axis
title_sort association of covid-19 inflammation with activation of the c5a-c5ar1 axis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7116884/
https://www.ncbi.nlm.nih.gov/pubmed/32726800
http://dx.doi.org/10.1038/s41586-020-2600-6
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