TMPRSS2: A potential target for treatment of influenza virus and coronavirus infections

Influenza virus and coronavirus epidemics or pandemics have occurred in succession worldwide throughout the early 21st century. These epidemics or pandemics pose a major threat to human health. Here, we outline a critical role of the host cell protease TMPRSS2 in influenza virus and coronavirus infe...

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Detalles Bibliográficos
Autores principales: Shen, Li Wen, Mao, Hui Juan, Wu, Yan Ling, Tanaka, Yoshimasa, Zhang, Wen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. and Société Française de Biochimie et Biologie Moléculaire (SFBBM). 2017
Materias:
Mini-Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7116903/
https://www.ncbi.nlm.nih.gov/pubmed/28778717
http://dx.doi.org/10.1016/j.biochi.2017.07.016
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author Shen, Li Wen
Mao, Hui Juan
Wu, Yan Ling
Tanaka, Yoshimasa
Zhang, Wen
author_facet Shen, Li Wen
Mao, Hui Juan
Wu, Yan Ling
Tanaka, Yoshimasa
Zhang, Wen
author_sort Shen, Li Wen
collection PubMed
description Influenza virus and coronavirus epidemics or pandemics have occurred in succession worldwide throughout the early 21st century. These epidemics or pandemics pose a major threat to human health. Here, we outline a critical role of the host cell protease TMPRSS2 in influenza virus and coronavirus infections and highlight an antiviral therapeutic strategy targeting TMPRSS2.
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spelling pubmed-71169032020-04-02 TMPRSS2: A potential target for treatment of influenza virus and coronavirus infections Shen, Li Wen Mao, Hui Juan Wu, Yan Ling Tanaka, Yoshimasa Zhang, Wen Biochimie Mini-Review Influenza virus and coronavirus epidemics or pandemics have occurred in succession worldwide throughout the early 21st century. These epidemics or pandemics pose a major threat to human health. Here, we outline a critical role of the host cell protease TMPRSS2 in influenza virus and coronavirus infections and highlight an antiviral therapeutic strategy targeting TMPRSS2. Elsevier B.V. and Société Française de Biochimie et Biologie Moléculaire (SFBBM). 2017-11 2017-08-01 /pmc/articles/PMC7116903/ /pubmed/28778717 http://dx.doi.org/10.1016/j.biochi.2017.07.016 Text en © 2017 Elsevier B.V. and Société Française de Biochimie et Biologie Moléculaire (SFBBM). All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Mini-Review
Shen, Li Wen
Mao, Hui Juan
Wu, Yan Ling
Tanaka, Yoshimasa
Zhang, Wen
TMPRSS2: A potential target for treatment of influenza virus and coronavirus infections
title TMPRSS2: A potential target for treatment of influenza virus and coronavirus infections
title_full TMPRSS2: A potential target for treatment of influenza virus and coronavirus infections
title_fullStr TMPRSS2: A potential target for treatment of influenza virus and coronavirus infections
title_full_unstemmed TMPRSS2: A potential target for treatment of influenza virus and coronavirus infections
title_short TMPRSS2: A potential target for treatment of influenza virus and coronavirus infections
title_sort tmprss2: a potential target for treatment of influenza virus and coronavirus infections
topic Mini-Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7116903/
https://www.ncbi.nlm.nih.gov/pubmed/28778717
http://dx.doi.org/10.1016/j.biochi.2017.07.016
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