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An experimental study quantifying pulmonary ventilation on inhalation of aerosol under steady and episodic emission

Estimating inhalation dose accurately under realistic conditions can enhance the accuracy of risk assessment. Conventional methods to quantify aerosol concentration that susceptible victims in contaminated environments are exposed to use real time particle counters to measure concentrations in envir...

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Detalles Bibliográficos
Autores principales: Poon, Carmen K.M., Lai, Alvin C.K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7116912/
https://www.ncbi.nlm.nih.gov/pubmed/21752541
http://dx.doi.org/10.1016/j.jhazmat.2011.06.040
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author Poon, Carmen K.M.
Lai, Alvin C.K.
author_facet Poon, Carmen K.M.
Lai, Alvin C.K.
author_sort Poon, Carmen K.M.
collection PubMed
description Estimating inhalation dose accurately under realistic conditions can enhance the accuracy of risk assessment. Conventional methods to quantify aerosol concentration that susceptible victims in contaminated environments are exposed to use real time particle counters to measure concentrations in environments without occupancy. Breathing-induced airflow interacts and influences concentration around nostrils or mouth and alter the ultimate exposure. This subject has not yet been systematically studied, particularly under transient emission. In this work, an experimental facility comprising two manikins was designed and fabricated. One of them mimicked realistic breathing, acting as a susceptible victim. Both steady and episodic emissions were generated in an air-conditioned environmental chamber in which two different ventilation schemes were tested. The scaled-dose of the victim under different expiratory velocities and pulmonary ventilation was measured. Inferring from results obtained from comprehensive tests, it can be concluded that breathing has very significant influence on the ultimate dose compared with that without breathing. Majority of results show that breathing reduces inhalation quantity and the reduction magnitude increases with breathing rate. This is attributed to the fact that the exhalation process plays a more significant role in reducing the dose level than the enhanced effect during inhalation period. The higher the breathing rate, the sharper the decline of the resultant concentration would be leading to lower dose. Nevertheless, under low pulmonary ventilation, results show that breathing increases dose marginally. Results also reveals that ventilation scheme also affects the exposure.
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spelling pubmed-71169122020-04-02 An experimental study quantifying pulmonary ventilation on inhalation of aerosol under steady and episodic emission Poon, Carmen K.M. Lai, Alvin C.K. J Hazard Mater Article Estimating inhalation dose accurately under realistic conditions can enhance the accuracy of risk assessment. Conventional methods to quantify aerosol concentration that susceptible victims in contaminated environments are exposed to use real time particle counters to measure concentrations in environments without occupancy. Breathing-induced airflow interacts and influences concentration around nostrils or mouth and alter the ultimate exposure. This subject has not yet been systematically studied, particularly under transient emission. In this work, an experimental facility comprising two manikins was designed and fabricated. One of them mimicked realistic breathing, acting as a susceptible victim. Both steady and episodic emissions were generated in an air-conditioned environmental chamber in which two different ventilation schemes were tested. The scaled-dose of the victim under different expiratory velocities and pulmonary ventilation was measured. Inferring from results obtained from comprehensive tests, it can be concluded that breathing has very significant influence on the ultimate dose compared with that without breathing. Majority of results show that breathing reduces inhalation quantity and the reduction magnitude increases with breathing rate. This is attributed to the fact that the exhalation process plays a more significant role in reducing the dose level than the enhanced effect during inhalation period. The higher the breathing rate, the sharper the decline of the resultant concentration would be leading to lower dose. Nevertheless, under low pulmonary ventilation, results show that breathing increases dose marginally. Results also reveals that ventilation scheme also affects the exposure. Elsevier B.V. 2011-09-15 2011-06-20 /pmc/articles/PMC7116912/ /pubmed/21752541 http://dx.doi.org/10.1016/j.jhazmat.2011.06.040 Text en Copyright © 2011 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Poon, Carmen K.M.
Lai, Alvin C.K.
An experimental study quantifying pulmonary ventilation on inhalation of aerosol under steady and episodic emission
title An experimental study quantifying pulmonary ventilation on inhalation of aerosol under steady and episodic emission
title_full An experimental study quantifying pulmonary ventilation on inhalation of aerosol under steady and episodic emission
title_fullStr An experimental study quantifying pulmonary ventilation on inhalation of aerosol under steady and episodic emission
title_full_unstemmed An experimental study quantifying pulmonary ventilation on inhalation of aerosol under steady and episodic emission
title_short An experimental study quantifying pulmonary ventilation on inhalation of aerosol under steady and episodic emission
title_sort experimental study quantifying pulmonary ventilation on inhalation of aerosol under steady and episodic emission
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7116912/
https://www.ncbi.nlm.nih.gov/pubmed/21752541
http://dx.doi.org/10.1016/j.jhazmat.2011.06.040
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