Two-way antigenic cross-reactivity between porcine epidemic diarrhea virus and porcine deltacoronavirus

Porcine epidemic diarrhea virus (PEDV) and porcine deltacoronavirus (PdCV) cause indistinguishable clinical signs and pathological changes in swine. Here we investigated the antigenic relationship between PEDV and PdCV. We provide the first evidence that conserved epitope(s) on the respective viral...

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Autores principales: Ma, Yuanmei, Zhang, Yu, Liang, Xueya, Oglesbee, Michael, Krakowka, Steven, Niehaus, Andrew, Wang, Guiping, Jia, Aiqing, Song, Houhui, Li, Jianrong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2016
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7117190/
https://www.ncbi.nlm.nih.gov/pubmed/27016762
http://dx.doi.org/10.1016/j.vetmic.2016.02.004
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author Ma, Yuanmei
Zhang, Yu
Liang, Xueya
Oglesbee, Michael
Krakowka, Steven
Niehaus, Andrew
Wang, Guiping
Jia, Aiqing
Song, Houhui
Li, Jianrong
author_facet Ma, Yuanmei
Zhang, Yu
Liang, Xueya
Oglesbee, Michael
Krakowka, Steven
Niehaus, Andrew
Wang, Guiping
Jia, Aiqing
Song, Houhui
Li, Jianrong
author_sort Ma, Yuanmei
collection PubMed
description Porcine epidemic diarrhea virus (PEDV) and porcine deltacoronavirus (PdCV) cause indistinguishable clinical signs and pathological changes in swine. Here we investigated the antigenic relationship between PEDV and PdCV. We provide the first evidence that conserved epitope(s) on the respective viral nucleocapsid proteins cross-react with each other although virus neutralization cross-reactivity was not observed. As a practical matter, prevention of these two very similar diseases of swine will require the development of separate virus-specific vaccine products.
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spelling pubmed-71171902020-04-02 Two-way antigenic cross-reactivity between porcine epidemic diarrhea virus and porcine deltacoronavirus Ma, Yuanmei Zhang, Yu Liang, Xueya Oglesbee, Michael Krakowka, Steven Niehaus, Andrew Wang, Guiping Jia, Aiqing Song, Houhui Li, Jianrong Vet Microbiol Short Communication Porcine epidemic diarrhea virus (PEDV) and porcine deltacoronavirus (PdCV) cause indistinguishable clinical signs and pathological changes in swine. Here we investigated the antigenic relationship between PEDV and PdCV. We provide the first evidence that conserved epitope(s) on the respective viral nucleocapsid proteins cross-react with each other although virus neutralization cross-reactivity was not observed. As a practical matter, prevention of these two very similar diseases of swine will require the development of separate virus-specific vaccine products. Elsevier B.V. 2016-04-15 2016-02-09 /pmc/articles/PMC7117190/ /pubmed/27016762 http://dx.doi.org/10.1016/j.vetmic.2016.02.004 Text en Copyright © 2016 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Short Communication
Ma, Yuanmei
Zhang, Yu
Liang, Xueya
Oglesbee, Michael
Krakowka, Steven
Niehaus, Andrew
Wang, Guiping
Jia, Aiqing
Song, Houhui
Li, Jianrong
Two-way antigenic cross-reactivity between porcine epidemic diarrhea virus and porcine deltacoronavirus
title Two-way antigenic cross-reactivity between porcine epidemic diarrhea virus and porcine deltacoronavirus
title_full Two-way antigenic cross-reactivity between porcine epidemic diarrhea virus and porcine deltacoronavirus
title_fullStr Two-way antigenic cross-reactivity between porcine epidemic diarrhea virus and porcine deltacoronavirus
title_full_unstemmed Two-way antigenic cross-reactivity between porcine epidemic diarrhea virus and porcine deltacoronavirus
title_short Two-way antigenic cross-reactivity between porcine epidemic diarrhea virus and porcine deltacoronavirus
title_sort two-way antigenic cross-reactivity between porcine epidemic diarrhea virus and porcine deltacoronavirus
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7117190/
https://www.ncbi.nlm.nih.gov/pubmed/27016762
http://dx.doi.org/10.1016/j.vetmic.2016.02.004
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