Cargando…

A method to provide improved dose–response estimates for airborne pathogens in animals: An example using porcine reproductive and respiratory syndrome virus

This paper describes a method to provide improved probability estimates that exposure to a specific dose of an airborne infectious pathogen will result in animal infection. Individual animals were exposed to a specific dose of airborne pathogen. Following exposure, animals were individually housed a...

Descripción completa

Detalles Bibliográficos
Autores principales: Hermann, J.R., Muñoz-Zanzi, C.A., Zimmerman, J.J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. Published by Elsevier B.V. 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7117404/
https://www.ncbi.nlm.nih.gov/pubmed/18778902
http://dx.doi.org/10.1016/j.vetmic.2008.07.002
_version_ 1783514363154399232
author Hermann, J.R.
Muñoz-Zanzi, C.A.
Zimmerman, J.J.
author_facet Hermann, J.R.
Muñoz-Zanzi, C.A.
Zimmerman, J.J.
author_sort Hermann, J.R.
collection PubMed
description This paper describes a method to provide improved probability estimates that exposure to a specific dose of an airborne infectious pathogen will result in animal infection. Individual animals were exposed to a specific dose of airborne pathogen. Following exposure, animals were individually housed and monitored for evidence of infection. The detection of specific antibodies and/or the pathogen in diagnostic specimens was evidence that the exposure dose resulted in infection. If replicated over a range of doses, the results can be used to derive a dose–response curve for a variety of animal species and infectious pathogens. This information is useful in estimating the likelihood of infection associated with exposure to airborne infectious microorganisms. Applications include predicting the risk of transmission associated with exposure to airborne pathogens, modeling the transmission of airborne pathogens, and determining requirements for effective exposure doses for vaccines delivered in aerosols.
format Online
Article
Text
id pubmed-7117404
institution National Center for Biotechnology Information
language English
publishDate 2009
publisher Elsevier B.V. Published by Elsevier B.V.
record_format MEDLINE/PubMed
spelling pubmed-71174042020-04-02 A method to provide improved dose–response estimates for airborne pathogens in animals: An example using porcine reproductive and respiratory syndrome virus Hermann, J.R. Muñoz-Zanzi, C.A. Zimmerman, J.J. Vet Microbiol Article This paper describes a method to provide improved probability estimates that exposure to a specific dose of an airborne infectious pathogen will result in animal infection. Individual animals were exposed to a specific dose of airborne pathogen. Following exposure, animals were individually housed and monitored for evidence of infection. The detection of specific antibodies and/or the pathogen in diagnostic specimens was evidence that the exposure dose resulted in infection. If replicated over a range of doses, the results can be used to derive a dose–response curve for a variety of animal species and infectious pathogens. This information is useful in estimating the likelihood of infection associated with exposure to airborne infectious microorganisms. Applications include predicting the risk of transmission associated with exposure to airborne pathogens, modeling the transmission of airborne pathogens, and determining requirements for effective exposure doses for vaccines delivered in aerosols. Elsevier B.V. Published by Elsevier B.V. 2009-01-13 2008-07-25 /pmc/articles/PMC7117404/ /pubmed/18778902 http://dx.doi.org/10.1016/j.vetmic.2008.07.002 Text en Copyright © 2008 Elsevier B.V. Published by Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Hermann, J.R.
Muñoz-Zanzi, C.A.
Zimmerman, J.J.
A method to provide improved dose–response estimates for airborne pathogens in animals: An example using porcine reproductive and respiratory syndrome virus
title A method to provide improved dose–response estimates for airborne pathogens in animals: An example using porcine reproductive and respiratory syndrome virus
title_full A method to provide improved dose–response estimates for airborne pathogens in animals: An example using porcine reproductive and respiratory syndrome virus
title_fullStr A method to provide improved dose–response estimates for airborne pathogens in animals: An example using porcine reproductive and respiratory syndrome virus
title_full_unstemmed A method to provide improved dose–response estimates for airborne pathogens in animals: An example using porcine reproductive and respiratory syndrome virus
title_short A method to provide improved dose–response estimates for airborne pathogens in animals: An example using porcine reproductive and respiratory syndrome virus
title_sort method to provide improved dose–response estimates for airborne pathogens in animals: an example using porcine reproductive and respiratory syndrome virus
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7117404/
https://www.ncbi.nlm.nih.gov/pubmed/18778902
http://dx.doi.org/10.1016/j.vetmic.2008.07.002
work_keys_str_mv AT hermannjr amethodtoprovideimproveddoseresponseestimatesforairbornepathogensinanimalsanexampleusingporcinereproductiveandrespiratorysyndromevirus
AT munozzanzica amethodtoprovideimproveddoseresponseestimatesforairbornepathogensinanimalsanexampleusingporcinereproductiveandrespiratorysyndromevirus
AT zimmermanjj amethodtoprovideimproveddoseresponseestimatesforairbornepathogensinanimalsanexampleusingporcinereproductiveandrespiratorysyndromevirus
AT hermannjr methodtoprovideimproveddoseresponseestimatesforairbornepathogensinanimalsanexampleusingporcinereproductiveandrespiratorysyndromevirus
AT munozzanzica methodtoprovideimproveddoseresponseestimatesforairbornepathogensinanimalsanexampleusingporcinereproductiveandrespiratorysyndromevirus
AT zimmermanjj methodtoprovideimproveddoseresponseestimatesforairbornepathogensinanimalsanexampleusingporcinereproductiveandrespiratorysyndromevirus