Assessment of noninvasive positive pressure ventilation in healthy young volunteers using salivary stress biomarkers

AIM: We performed a stress assessment of noninvasive positive pressure ventilation (NPPV) using the salivary biomarkers chromogranin A. MATERIALS & METHODS: Twenty healthy volunteers were subjected to NPPV for 30 min. We collected saliva samples before and after NPPV and evaluated chromogranin A...

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Detalles Bibliográficos
Autores principales: Fueda, Yuri, Matsuda, Fuka, Kataoka, Takuya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Future Science Ltd 2020
Materias:
Preliminary Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7117558/
https://www.ncbi.nlm.nih.gov/pubmed/32257373
http://dx.doi.org/10.2144/fsoa-2019-0150
Descripción
Sumario:AIM: We performed a stress assessment of noninvasive positive pressure ventilation (NPPV) using the salivary biomarkers chromogranin A. MATERIALS & METHODS: Twenty healthy volunteers were subjected to NPPV for 30 min. We collected saliva samples before and after NPPV and evaluated chromogranin A. RESULTS: We collected saliva samples from 13 volunteers for enzyme measurement. Of the 13 volunteers, 11 showed elevated chromogranin A levels, which were significantly higher after NPPV than before NPPV (p < 0.01). The chromogranin A increase group displayed significantly increased leak flow and reduced respiratory rate and absolute humidity compared with the chromogranin A reduction group. CONCLUSION: The increase of leak volume might be a stress factor in patients receiving NPPV.

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