A homogeneous SIRPα-CD47 cell-based, ligand-binding assay: Utility for small molecule drug development in immuno-oncology

CD47 is an immune checkpoint protein that downregulates both the innate and adaptive anti-tumor immune response via its counter receptor SIRPα. Biologics, including humanized CD47 monoclonal antibodies and decoy SIRPα receptors, that block the SIRPα-CD47 interaction, are currently being developed as...

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Detalles Bibliográficos
Autores principales: Burgess, Teresa L., Amason, Joshua D., Rubin, Jeffrey S., Duveau, Damien Y., Lamy, Laurence, Roberts, David D., Farrell, Catherine L., Inglese, James, Thomas, Craig J., Miller, Thomas W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7117682/
https://www.ncbi.nlm.nih.gov/pubmed/32240171
http://dx.doi.org/10.1371/journal.pone.0226661

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