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Prevalence of anemia in predialysis chronic kidney disease: Is the study center a significant factor?

OBJECTIVES: Anemia is highly prevalent in chronic kidney disease patients; however, its identification and management have been reported to be suboptimal. In this study we aimed to describe the prevalence, severity, risk factors, and treatment of anemia in different nephrology centers, among chronic...

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Autores principales: Alagoz, Selma, Dincer, Mevlut Tamer, Eren, Necmi, Bakir, Alev, Pekpak, Meltem, Trabulus, Sinan, Seyahi, Nurhan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7117725/
https://www.ncbi.nlm.nih.gov/pubmed/32240223
http://dx.doi.org/10.1371/journal.pone.0230980
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author Alagoz, Selma
Dincer, Mevlut Tamer
Eren, Necmi
Bakir, Alev
Pekpak, Meltem
Trabulus, Sinan
Seyahi, Nurhan
author_facet Alagoz, Selma
Dincer, Mevlut Tamer
Eren, Necmi
Bakir, Alev
Pekpak, Meltem
Trabulus, Sinan
Seyahi, Nurhan
author_sort Alagoz, Selma
collection PubMed
description OBJECTIVES: Anemia is highly prevalent in chronic kidney disease patients; however, its identification and management have been reported to be suboptimal. In this study we aimed to describe the prevalence, severity, risk factors, and treatment of anemia in different nephrology centers, among chronic kidney disease patients who were not given renal replacement therapy. MATERIALS AND METHODS: We performed a multicenter cross-sectional study in three different nephrology clinics. Adult (>18 years of age) chronic kidney disease patients with an estimated glomerular filtration rate (eGFR) below 60 ml/min, and who were not started dialysis were recruited. Demographic, clinical and laboratory data regarding anemia and its management were collected using a standard data form. Anemia was defined as a hemoglobin level below 12g/dL and severe anemia as a hemoglobin level below 10g/dl. RESULTS: A total of 1066 patients were enrolled in the study. Anemia and severe anemia were present in 55.9% and 14.9% of the patients, respectively. The mean hemoglobin level for the whole cohort was 11.8±1.8 g/dL. Univariate analyses revealed that the mean hemoglobin level was significantly different among the centers. Moreover, the frequency of the presence of anemia stratified by severity was also significantly different among the centers. According to binary logistic regression analysis, gender, levels of eGFR and iron, ferritin ≥ 100 ng/mL, and the nephrology center were independent determinants of severe anemia. CONCLUSIONS: We found a high prevalence of anemia among chronic kidney disease patients who were not on renal replacement therapy. Each center should determine the treatment strategy according to the patient’s characteristics. According to our results, the center-specific management of anemia seems to be important.
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spelling pubmed-71177252020-04-09 Prevalence of anemia in predialysis chronic kidney disease: Is the study center a significant factor? Alagoz, Selma Dincer, Mevlut Tamer Eren, Necmi Bakir, Alev Pekpak, Meltem Trabulus, Sinan Seyahi, Nurhan PLoS One Research Article OBJECTIVES: Anemia is highly prevalent in chronic kidney disease patients; however, its identification and management have been reported to be suboptimal. In this study we aimed to describe the prevalence, severity, risk factors, and treatment of anemia in different nephrology centers, among chronic kidney disease patients who were not given renal replacement therapy. MATERIALS AND METHODS: We performed a multicenter cross-sectional study in three different nephrology clinics. Adult (>18 years of age) chronic kidney disease patients with an estimated glomerular filtration rate (eGFR) below 60 ml/min, and who were not started dialysis were recruited. Demographic, clinical and laboratory data regarding anemia and its management were collected using a standard data form. Anemia was defined as a hemoglobin level below 12g/dL and severe anemia as a hemoglobin level below 10g/dl. RESULTS: A total of 1066 patients were enrolled in the study. Anemia and severe anemia were present in 55.9% and 14.9% of the patients, respectively. The mean hemoglobin level for the whole cohort was 11.8±1.8 g/dL. Univariate analyses revealed that the mean hemoglobin level was significantly different among the centers. Moreover, the frequency of the presence of anemia stratified by severity was also significantly different among the centers. According to binary logistic regression analysis, gender, levels of eGFR and iron, ferritin ≥ 100 ng/mL, and the nephrology center were independent determinants of severe anemia. CONCLUSIONS: We found a high prevalence of anemia among chronic kidney disease patients who were not on renal replacement therapy. Each center should determine the treatment strategy according to the patient’s characteristics. According to our results, the center-specific management of anemia seems to be important. Public Library of Science 2020-04-02 /pmc/articles/PMC7117725/ /pubmed/32240223 http://dx.doi.org/10.1371/journal.pone.0230980 Text en © 2020 Alagoz et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Alagoz, Selma
Dincer, Mevlut Tamer
Eren, Necmi
Bakir, Alev
Pekpak, Meltem
Trabulus, Sinan
Seyahi, Nurhan
Prevalence of anemia in predialysis chronic kidney disease: Is the study center a significant factor?
title Prevalence of anemia in predialysis chronic kidney disease: Is the study center a significant factor?
title_full Prevalence of anemia in predialysis chronic kidney disease: Is the study center a significant factor?
title_fullStr Prevalence of anemia in predialysis chronic kidney disease: Is the study center a significant factor?
title_full_unstemmed Prevalence of anemia in predialysis chronic kidney disease: Is the study center a significant factor?
title_short Prevalence of anemia in predialysis chronic kidney disease: Is the study center a significant factor?
title_sort prevalence of anemia in predialysis chronic kidney disease: is the study center a significant factor?
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7117725/
https://www.ncbi.nlm.nih.gov/pubmed/32240223
http://dx.doi.org/10.1371/journal.pone.0230980
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