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Increased Osteoclast and Decreased Osteoblast Activity Causes Reduced Bone Mineral Density and Quality in Genetic Hypercalciuric Stone‐Forming Rats

To study human idiopathic hypercalciuria (IH), we developed an animal model, genetic hypercalciuric stone‐forming (GHS) rats, whose pathophysiology parallels that in IH. All GHS rats form kidney stones and have decreased BMD and bone quality compared with the founder Sprague–Dawley (SD) rats. To und...

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Detalles Bibliográficos
Autores principales:	Krieger, Nancy S, Chen, Luojing, Becker, Jennifer, DeBoyace, Sean, Wang, Hongwei, Favus, Murray J, Bushinsky, David A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley & Sons, Ltd 2020
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7117851/ https://www.ncbi.nlm.nih.gov/pubmed/32258968 http://dx.doi.org/10.1002/jbm4.10350

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