Preclinical evaluation of a novel triple-acting PIM/PI3K/mTOR inhibitor, IBL-302, in breast cancer

The proviral integration of Moloney virus (PIM) family of protein kinases are overexpressed in many haematological and solid tumours. PIM kinase expression is elevated in PI3K inhibitor-treated breast cancer samples, suggesting a major resistance pathway for PI3K inhibitors in breast cancer, potenti...

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Detalles Bibliográficos
Autores principales: Kennedy, Sean P., O’Neill, Michael, Cunningham, Darren, Morris, Patrick G., Toomey, Sinead, Blanco-Aparicio, Carmen, Martinez, Sonia, Pastor, Joaquin, Eustace, Alex J., Hennessy, Bryan T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7118022/
https://www.ncbi.nlm.nih.gov/pubmed/32042115
http://dx.doi.org/10.1038/s41388-020-1202-y

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