Neuroprotective Effects of Doxycycline in the R6/2 Mouse Model of Huntington’s Disease

Mechanisms of tissue damage in Huntington’s disease involve excitotoxicity, mitochondrial damage, and inflammation, including microglia activation. Immunomodulatory and anti-protein aggregation properties of tetracyclines were demonstrated in several disease models. In the present study, the neuropr...

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Detalles Bibliográficos
Autores principales: Paldino, Emanuela, Balducci, Claudia, La Vitola, Pietro, Artioli, Luisa, D’Angelo, Vincenza, Giampà, Carmela, Artuso, Vladimiro, Forloni, Gianluigi, Fusco, Francesca R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7118056/
https://www.ncbi.nlm.nih.gov/pubmed/31879858
http://dx.doi.org/10.1007/s12035-019-01847-8

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