Airway Epithelial Dynamics in Allergy and Related Chronic Inflammatory Airway Diseases

Allergic rhinitis, chronic rhinosinusitis, and asthma are highly prevalent, multifactorial chronic airway diseases. Several environmental and genetic factors affect airway epithelial dynamics leading to activation of inflammatory mechanisms in the airways. This review links environmental factors to...

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Autores principales: Laulajainen-Hongisto, Anu, Toppila-Salmi, Sanna Katriina, Luukkainen, Annika, Kern, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7118214/
https://www.ncbi.nlm.nih.gov/pubmed/32292784
http://dx.doi.org/10.3389/fcell.2020.00204
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author Laulajainen-Hongisto, Anu
Toppila-Salmi, Sanna Katriina
Luukkainen, Annika
Kern, Robert
author_facet Laulajainen-Hongisto, Anu
Toppila-Salmi, Sanna Katriina
Luukkainen, Annika
Kern, Robert
author_sort Laulajainen-Hongisto, Anu
collection PubMed
description Allergic rhinitis, chronic rhinosinusitis, and asthma are highly prevalent, multifactorial chronic airway diseases. Several environmental and genetic factors affect airway epithelial dynamics leading to activation of inflammatory mechanisms in the airways. This review links environmental factors to host epithelial immunity in airway diseases. Understanding altered homeostasis of the airway epithelium might provide important targets for diagnostics and therapy of chronic airway diseases.
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spelling pubmed-71182142020-04-14 Airway Epithelial Dynamics in Allergy and Related Chronic Inflammatory Airway Diseases Laulajainen-Hongisto, Anu Toppila-Salmi, Sanna Katriina Luukkainen, Annika Kern, Robert Front Cell Dev Biol Cell and Developmental Biology Allergic rhinitis, chronic rhinosinusitis, and asthma are highly prevalent, multifactorial chronic airway diseases. Several environmental and genetic factors affect airway epithelial dynamics leading to activation of inflammatory mechanisms in the airways. This review links environmental factors to host epithelial immunity in airway diseases. Understanding altered homeostasis of the airway epithelium might provide important targets for diagnostics and therapy of chronic airway diseases. Frontiers Media S.A. 2020-03-27 /pmc/articles/PMC7118214/ /pubmed/32292784 http://dx.doi.org/10.3389/fcell.2020.00204 Text en Copyright © 2020 Laulajainen-Hongisto, Toppila-Salmi, Luukkainen and Kern. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Laulajainen-Hongisto, Anu
Toppila-Salmi, Sanna Katriina
Luukkainen, Annika
Kern, Robert
Airway Epithelial Dynamics in Allergy and Related Chronic Inflammatory Airway Diseases
title Airway Epithelial Dynamics in Allergy and Related Chronic Inflammatory Airway Diseases
title_full Airway Epithelial Dynamics in Allergy and Related Chronic Inflammatory Airway Diseases
title_fullStr Airway Epithelial Dynamics in Allergy and Related Chronic Inflammatory Airway Diseases
title_full_unstemmed Airway Epithelial Dynamics in Allergy and Related Chronic Inflammatory Airway Diseases
title_short Airway Epithelial Dynamics in Allergy and Related Chronic Inflammatory Airway Diseases
title_sort airway epithelial dynamics in allergy and related chronic inflammatory airway diseases
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7118214/
https://www.ncbi.nlm.nih.gov/pubmed/32292784
http://dx.doi.org/10.3389/fcell.2020.00204
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