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Interictal magnetoencephalography in parietal lobe epilepsy – Comparison of equivalent current dipole and beamformer (SAMepi) analysis
OBJECTIVE: To evaluate a novel analysis method (SAMepi) in the localization of interictal epileptiform magnetoencephalographic (MEG) activity in parietal lobe epilepsy (PLE) patients in comparison with equivalent current dipole (ECD) analysis. METHODS: We analyzed the preoperative interictal MEG of...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7118275/ https://www.ncbi.nlm.nih.gov/pubmed/32258834 http://dx.doi.org/10.1016/j.cnp.2020.02.003 |
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author | Wilenius, Juha Lauronen, Leena Kirveskari, Erika Gaily, Eija Metsähonkala, Liisa Paetau, Ritva |
author_facet | Wilenius, Juha Lauronen, Leena Kirveskari, Erika Gaily, Eija Metsähonkala, Liisa Paetau, Ritva |
author_sort | Wilenius, Juha |
collection | PubMed |
description | OBJECTIVE: To evaluate a novel analysis method (SAMepi) in the localization of interictal epileptiform magnetoencephalographic (MEG) activity in parietal lobe epilepsy (PLE) patients in comparison with equivalent current dipole (ECD) analysis. METHODS: We analyzed the preoperative interictal MEG of 17 operated PLE patients utilizing visual analysis and: (1) ECD with a spherical conductor model; (2) ECD with a boundary element method (BEM) conductor model; and (3) SAMepi – a kurtosis beamformer method. Localization results were compared between the three methods, to the location of the resection and to the clinical outcome. RESULTS: Fourteen patients had an epileptiform finding in the visual analysis; SAMepi detected spikes in 11 of them. A unifocal finding in both the ECD and in the SAMepi analysis was associated with a better chance of seizure-freedom (p = 0.02). There was no significant difference in the distances from the unifocal MEG localizations to the nearest border of the resection between the different analysis methods. CONCLUSIONS: Localizations of unifocal interictal spikes detected by SAMepi did not significantly differ from the conventional ECD localizations. SIGNIFICANCE: SAMepi – a novel semiautomatic analysis method – is useful in localizing interictal epileptiform MEG activity in the presurgical evaluation of parietal lobe epilepsy patients. |
format | Online Article Text |
id | pubmed-7118275 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-71182752020-04-06 Interictal magnetoencephalography in parietal lobe epilepsy – Comparison of equivalent current dipole and beamformer (SAMepi) analysis Wilenius, Juha Lauronen, Leena Kirveskari, Erika Gaily, Eija Metsähonkala, Liisa Paetau, Ritva Clin Neurophysiol Pract Clinical and Research Article OBJECTIVE: To evaluate a novel analysis method (SAMepi) in the localization of interictal epileptiform magnetoencephalographic (MEG) activity in parietal lobe epilepsy (PLE) patients in comparison with equivalent current dipole (ECD) analysis. METHODS: We analyzed the preoperative interictal MEG of 17 operated PLE patients utilizing visual analysis and: (1) ECD with a spherical conductor model; (2) ECD with a boundary element method (BEM) conductor model; and (3) SAMepi – a kurtosis beamformer method. Localization results were compared between the three methods, to the location of the resection and to the clinical outcome. RESULTS: Fourteen patients had an epileptiform finding in the visual analysis; SAMepi detected spikes in 11 of them. A unifocal finding in both the ECD and in the SAMepi analysis was associated with a better chance of seizure-freedom (p = 0.02). There was no significant difference in the distances from the unifocal MEG localizations to the nearest border of the resection between the different analysis methods. CONCLUSIONS: Localizations of unifocal interictal spikes detected by SAMepi did not significantly differ from the conventional ECD localizations. SIGNIFICANCE: SAMepi – a novel semiautomatic analysis method – is useful in localizing interictal epileptiform MEG activity in the presurgical evaluation of parietal lobe epilepsy patients. Elsevier 2020-03-10 /pmc/articles/PMC7118275/ /pubmed/32258834 http://dx.doi.org/10.1016/j.cnp.2020.02.003 Text en © 2020 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Clinical and Research Article Wilenius, Juha Lauronen, Leena Kirveskari, Erika Gaily, Eija Metsähonkala, Liisa Paetau, Ritva Interictal magnetoencephalography in parietal lobe epilepsy – Comparison of equivalent current dipole and beamformer (SAMepi) analysis |
title | Interictal magnetoencephalography in parietal lobe epilepsy – Comparison of equivalent current dipole and beamformer (SAMepi) analysis |
title_full | Interictal magnetoencephalography in parietal lobe epilepsy – Comparison of equivalent current dipole and beamformer (SAMepi) analysis |
title_fullStr | Interictal magnetoencephalography in parietal lobe epilepsy – Comparison of equivalent current dipole and beamformer (SAMepi) analysis |
title_full_unstemmed | Interictal magnetoencephalography in parietal lobe epilepsy – Comparison of equivalent current dipole and beamformer (SAMepi) analysis |
title_short | Interictal magnetoencephalography in parietal lobe epilepsy – Comparison of equivalent current dipole and beamformer (SAMepi) analysis |
title_sort | interictal magnetoencephalography in parietal lobe epilepsy – comparison of equivalent current dipole and beamformer (samepi) analysis |
topic | Clinical and Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7118275/ https://www.ncbi.nlm.nih.gov/pubmed/32258834 http://dx.doi.org/10.1016/j.cnp.2020.02.003 |
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