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Interictal magnetoencephalography in parietal lobe epilepsy – Comparison of equivalent current dipole and beamformer (SAMepi) analysis

OBJECTIVE: To evaluate a novel analysis method (SAMepi) in the localization of interictal epileptiform magnetoencephalographic (MEG) activity in parietal lobe epilepsy (PLE) patients in comparison with equivalent current dipole (ECD) analysis. METHODS: We analyzed the preoperative interictal MEG of...

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Autores principales: Wilenius, Juha, Lauronen, Leena, Kirveskari, Erika, Gaily, Eija, Metsähonkala, Liisa, Paetau, Ritva
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7118275/
https://www.ncbi.nlm.nih.gov/pubmed/32258834
http://dx.doi.org/10.1016/j.cnp.2020.02.003
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author Wilenius, Juha
Lauronen, Leena
Kirveskari, Erika
Gaily, Eija
Metsähonkala, Liisa
Paetau, Ritva
author_facet Wilenius, Juha
Lauronen, Leena
Kirveskari, Erika
Gaily, Eija
Metsähonkala, Liisa
Paetau, Ritva
author_sort Wilenius, Juha
collection PubMed
description OBJECTIVE: To evaluate a novel analysis method (SAMepi) in the localization of interictal epileptiform magnetoencephalographic (MEG) activity in parietal lobe epilepsy (PLE) patients in comparison with equivalent current dipole (ECD) analysis. METHODS: We analyzed the preoperative interictal MEG of 17 operated PLE patients utilizing visual analysis and: (1) ECD with a spherical conductor model; (2) ECD with a boundary element method (BEM) conductor model; and (3) SAMepi – a kurtosis beamformer method. Localization results were compared between the three methods, to the location of the resection and to the clinical outcome. RESULTS: Fourteen patients had an epileptiform finding in the visual analysis; SAMepi detected spikes in 11 of them. A unifocal finding in both the ECD and in the SAMepi analysis was associated with a better chance of seizure-freedom (p = 0.02). There was no significant difference in the distances from the unifocal MEG localizations to the nearest border of the resection between the different analysis methods. CONCLUSIONS: Localizations of unifocal interictal spikes detected by SAMepi did not significantly differ from the conventional ECD localizations. SIGNIFICANCE: SAMepi – a novel semiautomatic analysis method – is useful in localizing interictal epileptiform MEG activity in the presurgical evaluation of parietal lobe epilepsy patients.
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spelling pubmed-71182752020-04-06 Interictal magnetoencephalography in parietal lobe epilepsy – Comparison of equivalent current dipole and beamformer (SAMepi) analysis Wilenius, Juha Lauronen, Leena Kirveskari, Erika Gaily, Eija Metsähonkala, Liisa Paetau, Ritva Clin Neurophysiol Pract Clinical and Research Article OBJECTIVE: To evaluate a novel analysis method (SAMepi) in the localization of interictal epileptiform magnetoencephalographic (MEG) activity in parietal lobe epilepsy (PLE) patients in comparison with equivalent current dipole (ECD) analysis. METHODS: We analyzed the preoperative interictal MEG of 17 operated PLE patients utilizing visual analysis and: (1) ECD with a spherical conductor model; (2) ECD with a boundary element method (BEM) conductor model; and (3) SAMepi – a kurtosis beamformer method. Localization results were compared between the three methods, to the location of the resection and to the clinical outcome. RESULTS: Fourteen patients had an epileptiform finding in the visual analysis; SAMepi detected spikes in 11 of them. A unifocal finding in both the ECD and in the SAMepi analysis was associated with a better chance of seizure-freedom (p = 0.02). There was no significant difference in the distances from the unifocal MEG localizations to the nearest border of the resection between the different analysis methods. CONCLUSIONS: Localizations of unifocal interictal spikes detected by SAMepi did not significantly differ from the conventional ECD localizations. SIGNIFICANCE: SAMepi – a novel semiautomatic analysis method – is useful in localizing interictal epileptiform MEG activity in the presurgical evaluation of parietal lobe epilepsy patients. Elsevier 2020-03-10 /pmc/articles/PMC7118275/ /pubmed/32258834 http://dx.doi.org/10.1016/j.cnp.2020.02.003 Text en © 2020 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Clinical and Research Article
Wilenius, Juha
Lauronen, Leena
Kirveskari, Erika
Gaily, Eija
Metsähonkala, Liisa
Paetau, Ritva
Interictal magnetoencephalography in parietal lobe epilepsy – Comparison of equivalent current dipole and beamformer (SAMepi) analysis
title Interictal magnetoencephalography in parietal lobe epilepsy – Comparison of equivalent current dipole and beamformer (SAMepi) analysis
title_full Interictal magnetoencephalography in parietal lobe epilepsy – Comparison of equivalent current dipole and beamformer (SAMepi) analysis
title_fullStr Interictal magnetoencephalography in parietal lobe epilepsy – Comparison of equivalent current dipole and beamformer (SAMepi) analysis
title_full_unstemmed Interictal magnetoencephalography in parietal lobe epilepsy – Comparison of equivalent current dipole and beamformer (SAMepi) analysis
title_short Interictal magnetoencephalography in parietal lobe epilepsy – Comparison of equivalent current dipole and beamformer (SAMepi) analysis
title_sort interictal magnetoencephalography in parietal lobe epilepsy – comparison of equivalent current dipole and beamformer (samepi) analysis
topic Clinical and Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7118275/
https://www.ncbi.nlm.nih.gov/pubmed/32258834
http://dx.doi.org/10.1016/j.cnp.2020.02.003
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