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The Promising Role of miR-21 as a Cancer Biomarker and Its Importance in RNA-Based Therapeutics
MicroRNAs are small noncoding transcripts that posttranscriptionally regulate gene expression via base-pairing complementarity. Their role in cancer can be related to tumor suppression or oncogenic function. Moreover, they have been linked to processes recognized as hallmarks of cancer, such as apop...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society of Gene & Cell Therapy
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7118281/ https://www.ncbi.nlm.nih.gov/pubmed/32244168 http://dx.doi.org/10.1016/j.omtn.2020.03.003 |
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author | Bautista-Sánchez, Diana Arriaga-Canon, Cristian Pedroza-Torres, Abraham De La Rosa-Velázquez, Inti Alberto González-Barrios, Rodrigo Contreras-Espinosa, Laura Montiel-Manríquez, Rogelio Castro-Hernández, Clementina Fragoso-Ontiveros, Verónica Álvarez-Gómez, Rosa María Herrera, Luis A. |
author_facet | Bautista-Sánchez, Diana Arriaga-Canon, Cristian Pedroza-Torres, Abraham De La Rosa-Velázquez, Inti Alberto González-Barrios, Rodrigo Contreras-Espinosa, Laura Montiel-Manríquez, Rogelio Castro-Hernández, Clementina Fragoso-Ontiveros, Verónica Álvarez-Gómez, Rosa María Herrera, Luis A. |
author_sort | Bautista-Sánchez, Diana |
collection | PubMed |
description | MicroRNAs are small noncoding transcripts that posttranscriptionally regulate gene expression via base-pairing complementarity. Their role in cancer can be related to tumor suppression or oncogenic function. Moreover, they have been linked to processes recognized as hallmarks of cancer, such as apoptosis, invasion, metastasis, and proliferation. Particularly, one of the first oncomiRs found upregulated in a variety of cancers, such as gliomas, breast cancer, and colorectal cancer, was microRNA-21 (miR-21). Some of its target genes associated with cancer are PTEN (phosphatase and tensin homolog), PDCD4 (programmed cell death protein 4), RECK (reversion-inducing cysteine-rich protein with Kazal motifs), and STAT3 (signal transducer activator of transcription 3). As a result, miR-21 has been proposed as a plausible diagnostic and prognostic biomarker, as well as a therapeutic target for several types of cancer. Currently, research and clinical trials to inhibit miR-21 through anti-miR-21 oligonucleotides and ADM-21 are being conducted. As all of the evidence suggests, miR-21 is involved in carcinogenic processes; therefore, inhibiting it could have effects on more than one type of cancer. However, whether miR-21 can be used as a tissue-specific biomarker should be analyzed with caution. Consequently, the purpose of this review is to outline the available information and recent advances regarding miR-21 as a potential biomarker in the clinical setting and as a therapeutic target in cancer to highlight its importance in the era of precision medicine. |
format | Online Article Text |
id | pubmed-7118281 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | American Society of Gene & Cell Therapy |
record_format | MEDLINE/PubMed |
spelling | pubmed-71182812020-04-06 The Promising Role of miR-21 as a Cancer Biomarker and Its Importance in RNA-Based Therapeutics Bautista-Sánchez, Diana Arriaga-Canon, Cristian Pedroza-Torres, Abraham De La Rosa-Velázquez, Inti Alberto González-Barrios, Rodrigo Contreras-Espinosa, Laura Montiel-Manríquez, Rogelio Castro-Hernández, Clementina Fragoso-Ontiveros, Verónica Álvarez-Gómez, Rosa María Herrera, Luis A. Mol Ther Nucleic Acids Article MicroRNAs are small noncoding transcripts that posttranscriptionally regulate gene expression via base-pairing complementarity. Their role in cancer can be related to tumor suppression or oncogenic function. Moreover, they have been linked to processes recognized as hallmarks of cancer, such as apoptosis, invasion, metastasis, and proliferation. Particularly, one of the first oncomiRs found upregulated in a variety of cancers, such as gliomas, breast cancer, and colorectal cancer, was microRNA-21 (miR-21). Some of its target genes associated with cancer are PTEN (phosphatase and tensin homolog), PDCD4 (programmed cell death protein 4), RECK (reversion-inducing cysteine-rich protein with Kazal motifs), and STAT3 (signal transducer activator of transcription 3). As a result, miR-21 has been proposed as a plausible diagnostic and prognostic biomarker, as well as a therapeutic target for several types of cancer. Currently, research and clinical trials to inhibit miR-21 through anti-miR-21 oligonucleotides and ADM-21 are being conducted. As all of the evidence suggests, miR-21 is involved in carcinogenic processes; therefore, inhibiting it could have effects on more than one type of cancer. However, whether miR-21 can be used as a tissue-specific biomarker should be analyzed with caution. Consequently, the purpose of this review is to outline the available information and recent advances regarding miR-21 as a potential biomarker in the clinical setting and as a therapeutic target in cancer to highlight its importance in the era of precision medicine. American Society of Gene & Cell Therapy 2020-03-13 /pmc/articles/PMC7118281/ /pubmed/32244168 http://dx.doi.org/10.1016/j.omtn.2020.03.003 Text en © 2020 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Bautista-Sánchez, Diana Arriaga-Canon, Cristian Pedroza-Torres, Abraham De La Rosa-Velázquez, Inti Alberto González-Barrios, Rodrigo Contreras-Espinosa, Laura Montiel-Manríquez, Rogelio Castro-Hernández, Clementina Fragoso-Ontiveros, Verónica Álvarez-Gómez, Rosa María Herrera, Luis A. The Promising Role of miR-21 as a Cancer Biomarker and Its Importance in RNA-Based Therapeutics |
title | The Promising Role of miR-21 as a Cancer Biomarker and Its Importance in RNA-Based Therapeutics |
title_full | The Promising Role of miR-21 as a Cancer Biomarker and Its Importance in RNA-Based Therapeutics |
title_fullStr | The Promising Role of miR-21 as a Cancer Biomarker and Its Importance in RNA-Based Therapeutics |
title_full_unstemmed | The Promising Role of miR-21 as a Cancer Biomarker and Its Importance in RNA-Based Therapeutics |
title_short | The Promising Role of miR-21 as a Cancer Biomarker and Its Importance in RNA-Based Therapeutics |
title_sort | promising role of mir-21 as a cancer biomarker and its importance in rna-based therapeutics |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7118281/ https://www.ncbi.nlm.nih.gov/pubmed/32244168 http://dx.doi.org/10.1016/j.omtn.2020.03.003 |
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