Efficient and specific generation of knockout mice using Campylobacter jejuni CRISPR/Cas9 system

The Streptococcus pyogenes CRISPR/Cas9 (SpCas9) system is now widely utilized to generate genome engineered mice; however, some studies raised issues related to off-target mutations with this system. Herein, we utilized the Campylobacter jejuni Cas9 (CjCas9) system to generate knockout mice. We desi...

Descripción completa

Detalles Bibliográficos
Autores principales: Lee, Jae Young, Jang, Yoo Jin, Bae, Ji Hyun, Lee, Yoon Hoo, Bae, Hee Sook, Kim, Seokjoong, Park, Sin-Gi, Koo, Ok Jae, Yeom, Su Cheong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
SHORT COMMUNICATION
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7118303/
https://www.ncbi.nlm.nih.gov/pubmed/32258440
http://dx.doi.org/10.1016/j.bbrep.2020.100752

Ejemplares similares

Ejemplares similares