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非小细胞肺癌原发灶与转移部位驱动基因状态一致性的研究进展
Non-small cell lung cancer (NSCLC), as the most common pathological type of lung cancer, has the characteristics of high malignancy and aggressiveness, and the lymph nodes and different organ metastases are prone to occur in advanced stages. In recent years, with the development of precision medicin...
Formato: | Online Artículo Texto |
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Lenguaje: | English |
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中国肺癌杂志编辑部
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7118335/ https://www.ncbi.nlm.nih.gov/pubmed/32102137 http://dx.doi.org/10.3779/j.issn.1009-3419.2020.03.10 |
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collection | PubMed |
description | Non-small cell lung cancer (NSCLC), as the most common pathological type of lung cancer, has the characteristics of high malignancy and aggressiveness, and the lymph nodes and different organ metastases are prone to occur in advanced stages. In recent years, with the development of precision medicine, drug resistance and treatment failure in NSCLC metastasis sites have brought difficulties for molecular targeted therapy. And studies have confirmed that these may be related to new molecular changes after tumor metastasis. This review is to describe the state of the driving genes in the primary and metastatic sites of NSCLC, and systematically review the research progress on the consistency of the state of the driving genes between the primary and corresponding metastatic lesions, which provides a new idea for exploring the molecular targeted therapy of metastatic NSCLC. |
format | Online Article Text |
id | pubmed-7118335 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | 中国肺癌杂志编辑部 |
record_format | MEDLINE/PubMed |
spelling | pubmed-71183352020-04-07 非小细胞肺癌原发灶与转移部位驱动基因状态一致性的研究进展 Zhongguo Fei Ai Za Zhi 综述 Non-small cell lung cancer (NSCLC), as the most common pathological type of lung cancer, has the characteristics of high malignancy and aggressiveness, and the lymph nodes and different organ metastases are prone to occur in advanced stages. In recent years, with the development of precision medicine, drug resistance and treatment failure in NSCLC metastasis sites have brought difficulties for molecular targeted therapy. And studies have confirmed that these may be related to new molecular changes after tumor metastasis. This review is to describe the state of the driving genes in the primary and metastatic sites of NSCLC, and systematically review the research progress on the consistency of the state of the driving genes between the primary and corresponding metastatic lesions, which provides a new idea for exploring the molecular targeted therapy of metastatic NSCLC. 中国肺癌杂志编辑部 2020-03-20 /pmc/articles/PMC7118335/ /pubmed/32102137 http://dx.doi.org/10.3779/j.issn.1009-3419.2020.03.10 Text en 版权所有©《中国肺癌杂志》编辑部2020 This is an open access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY 3.0) License. See: https://creativecommons.org/licenses/by/3.0/. |
spellingShingle | 综述 非小细胞肺癌原发灶与转移部位驱动基因状态一致性的研究进展 |
title | 非小细胞肺癌原发灶与转移部位驱动基因状态一致性的研究进展 |
title_full | 非小细胞肺癌原发灶与转移部位驱动基因状态一致性的研究进展 |
title_fullStr | 非小细胞肺癌原发灶与转移部位驱动基因状态一致性的研究进展 |
title_full_unstemmed | 非小细胞肺癌原发灶与转移部位驱动基因状态一致性的研究进展 |
title_short | 非小细胞肺癌原发灶与转移部位驱动基因状态一致性的研究进展 |
title_sort | 非小细胞肺癌原发灶与转移部位驱动基因状态一致性的研究进展 |
topic | 综述 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7118335/ https://www.ncbi.nlm.nih.gov/pubmed/32102137 http://dx.doi.org/10.3779/j.issn.1009-3419.2020.03.10 |
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