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Mechanistic insights into differential requirement of receptor dimerization for oncogenic activation of mutant EGFR and its clinical perspective
The epidermal growth factor receptor (EGFR), a member of the ErbB family (EGFR, ErbB2, ErbB3 and ErbB4), plays a crucial role in regulating various cellular responses such as proliferation, differentiation, and survival. As a result, aberrant activation of EGFR, mostly mediated through different cla...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Korean Society for Biochemistry and Molecular Biology
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7118354/ https://www.ncbi.nlm.nih.gov/pubmed/32172728 http://dx.doi.org/10.5483/BMBRep.2020.53.3.025 |