Engineered transient and stable overexpression of translation factors eIF3i and eIF3c in CHOK1 and HEK293 cells gives enhanced cell growth associated with increased c-Myc expression and increased recombinant protein synthesis

There is a desire to engineer mammalian host cell lines to improve cell growth/biomass accumulation and recombinant biopharmaceutical protein production in industrially relevant cell lines such as the CHOK1 and HEK293 cell lines. The over-expression of individual subunits of the eukaryotic translati...

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Detalles Bibliográficos
Autores principales: Roobol, Anne, Roobol, Joanne, Smith, Matthew E., Carden, Martin J., Hershey, John W.B., Willis, Anne E., Smales, C. Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Academic Press 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7118365/
https://www.ncbi.nlm.nih.gov/pubmed/32061967
http://dx.doi.org/10.1016/j.ymben.2020.02.001

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