Plasticity of Lgr5-Negative Cancer Cells Drives Metastasis in Colorectal Cancer

Colorectal cancer stem cells (CSCs) express Lgr5 and display extensive stem cell-like multipotency and self-renewal and are thought to seed metastatic disease. Here, we used a mouse model of colorectal cancer (CRC) and human tumor xenografts to investigate the cell of origin of metastases. We found...

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Detalles Bibliográficos
Autores principales: Fumagalli, Arianna, Oost, Koen C., Kester, Lennart, Morgner, Jessica, Bornes, Laura, Bruens, Lotte, Spaargaren, Lisa, Azkanaz, Maria, Schelfhorst, Tim, Beerling, Evelyne, Heinz, Maria C., Postrach, Daniel, Seinstra, Danielle, Sieuwerts, Anieta M., Martens, John W.M., van der Elst, Stefan, van Baalen, Martijn, Bhowmick, Debajit, Vrisekoop, Nienke, Ellenbroek, Saskia I.J., Suijkerbuijk, Saskia J.E., Snippert, Hugo J., van Rheenen, Jacco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7118369/
https://www.ncbi.nlm.nih.gov/pubmed/32169167
http://dx.doi.org/10.1016/j.stem.2020.02.008

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