Marked Hypergastrinemia with G-cell Hyperplasia in Two Autoimmune Gastritis Patients

Gastrin regulates gastric acid secretion, and gastrin secretion itself is regulated by the negative feedback system of gastric acidity. Autoimmune gastritis (AG) is a disease where parietal cells are destroyed, resulting in decreased acid production and an elevated serum gastrin level. We herein rep...

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Detalles Bibliográficos
Autores principales: Watanabe, Hirotaka, Yoneda, Sho, Motoyama, Yuichi, Mukai, Kosuke, Okuno, Yosuke, Kozawa, Junji, Nishizawa, Hitoshi, Maeda, Norikazu, Otsuki, Michio, Matsuoka, Taka-aki, Morii, Eiichi, Iwahashi, Hiromi, Shimomura, Iichiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7118375/
https://www.ncbi.nlm.nih.gov/pubmed/31787690
http://dx.doi.org/10.2169/internalmedicine.3009-19
Descripción
Sumario:Gastrin regulates gastric acid secretion, and gastrin secretion itself is regulated by the negative feedback system of gastric acidity. Autoimmune gastritis (AG) is a disease where parietal cells are destroyed, resulting in decreased acid production and an elevated serum gastrin level. We herein report 2 AG cases with marked hypergastrinemia (>5,000 pg/mL). In both cases, 24-hour gastric pH monitoring showed no time when gastric pH was <2, and immunohistochemistry revealed more than 140 gastrin-positive cells per linear millimeter at the antral mucosa. This is the first report to confirm the relationship between marked hypergastrinemia and G-cell hyperplasia with AG.

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