Marked Hypergastrinemia with G-cell Hyperplasia in Two Autoimmune Gastritis Patients

Gastrin regulates gastric acid secretion, and gastrin secretion itself is regulated by the negative feedback system of gastric acidity. Autoimmune gastritis (AG) is a disease where parietal cells are destroyed, resulting in decreased acid production and an elevated serum gastrin level. We herein rep...

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Detalles Bibliográficos
Autores principales: Watanabe, Hirotaka, Yoneda, Sho, Motoyama, Yuichi, Mukai, Kosuke, Okuno, Yosuke, Kozawa, Junji, Nishizawa, Hitoshi, Maeda, Norikazu, Otsuki, Michio, Matsuoka, Taka-aki, Morii, Eiichi, Iwahashi, Hiromi, Shimomura, Iichiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7118375/
https://www.ncbi.nlm.nih.gov/pubmed/31787690
http://dx.doi.org/10.2169/internalmedicine.3009-19
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author Watanabe, Hirotaka
Yoneda, Sho
Motoyama, Yuichi
Mukai, Kosuke
Okuno, Yosuke
Kozawa, Junji
Nishizawa, Hitoshi
Maeda, Norikazu
Otsuki, Michio
Matsuoka, Taka-aki
Morii, Eiichi
Iwahashi, Hiromi
Shimomura, Iichiro
author_facet Watanabe, Hirotaka
Yoneda, Sho
Motoyama, Yuichi
Mukai, Kosuke
Okuno, Yosuke
Kozawa, Junji
Nishizawa, Hitoshi
Maeda, Norikazu
Otsuki, Michio
Matsuoka, Taka-aki
Morii, Eiichi
Iwahashi, Hiromi
Shimomura, Iichiro
author_sort Watanabe, Hirotaka
collection PubMed
description Gastrin regulates gastric acid secretion, and gastrin secretion itself is regulated by the negative feedback system of gastric acidity. Autoimmune gastritis (AG) is a disease where parietal cells are destroyed, resulting in decreased acid production and an elevated serum gastrin level. We herein report 2 AG cases with marked hypergastrinemia (>5,000 pg/mL). In both cases, 24-hour gastric pH monitoring showed no time when gastric pH was <2, and immunohistochemistry revealed more than 140 gastrin-positive cells per linear millimeter at the antral mucosa. This is the first report to confirm the relationship between marked hypergastrinemia and G-cell hyperplasia with AG.
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spelling pubmed-71183752020-04-07 Marked Hypergastrinemia with G-cell Hyperplasia in Two Autoimmune Gastritis Patients Watanabe, Hirotaka Yoneda, Sho Motoyama, Yuichi Mukai, Kosuke Okuno, Yosuke Kozawa, Junji Nishizawa, Hitoshi Maeda, Norikazu Otsuki, Michio Matsuoka, Taka-aki Morii, Eiichi Iwahashi, Hiromi Shimomura, Iichiro Intern Med Case Report Gastrin regulates gastric acid secretion, and gastrin secretion itself is regulated by the negative feedback system of gastric acidity. Autoimmune gastritis (AG) is a disease where parietal cells are destroyed, resulting in decreased acid production and an elevated serum gastrin level. We herein report 2 AG cases with marked hypergastrinemia (>5,000 pg/mL). In both cases, 24-hour gastric pH monitoring showed no time when gastric pH was <2, and immunohistochemistry revealed more than 140 gastrin-positive cells per linear millimeter at the antral mucosa. This is the first report to confirm the relationship between marked hypergastrinemia and G-cell hyperplasia with AG. The Japanese Society of Internal Medicine 2019-11-29 2020-03-15 /pmc/articles/PMC7118375/ /pubmed/31787690 http://dx.doi.org/10.2169/internalmedicine.3009-19 Text en Copyright © 2020 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Watanabe, Hirotaka
Yoneda, Sho
Motoyama, Yuichi
Mukai, Kosuke
Okuno, Yosuke
Kozawa, Junji
Nishizawa, Hitoshi
Maeda, Norikazu
Otsuki, Michio
Matsuoka, Taka-aki
Morii, Eiichi
Iwahashi, Hiromi
Shimomura, Iichiro
Marked Hypergastrinemia with G-cell Hyperplasia in Two Autoimmune Gastritis Patients
title Marked Hypergastrinemia with G-cell Hyperplasia in Two Autoimmune Gastritis Patients
title_full Marked Hypergastrinemia with G-cell Hyperplasia in Two Autoimmune Gastritis Patients
title_fullStr Marked Hypergastrinemia with G-cell Hyperplasia in Two Autoimmune Gastritis Patients
title_full_unstemmed Marked Hypergastrinemia with G-cell Hyperplasia in Two Autoimmune Gastritis Patients
title_short Marked Hypergastrinemia with G-cell Hyperplasia in Two Autoimmune Gastritis Patients
title_sort marked hypergastrinemia with g-cell hyperplasia in two autoimmune gastritis patients
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7118375/
https://www.ncbi.nlm.nih.gov/pubmed/31787690
http://dx.doi.org/10.2169/internalmedicine.3009-19
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