Hb Phnom Penh Showing Falsely High or Reasonable HbA1c Values Depending on the Type of High-performance Liquid Chromatography System

We herein report a 50-year-old Chinese woman with Hb Phnom Penh (α117Phe-Ile-α118Thr) showing high or reasonable HbA1c values depending on the type of high-performance liquid chromatography (HPLC) system. A high HbA1c value of 7.5% (HPLC assay: G9) and a reasonable HbA1c value of 5.2% (assay unknown...

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Autores principales: Hara, Kenji, Koga, Masafumi, Shinozaki, Hiroyuki, Yamauchi, Mototaka, Suzuki, Tatsuhiko, Naruse, Rika, Tsuchiya, Takafumi, Takebayashi, Kohzo, Inukai, Toshihiko, Hashimoto, Koshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7118387/
https://www.ncbi.nlm.nih.gov/pubmed/31787693
http://dx.doi.org/10.2169/internalmedicine.3306-19
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author Hara, Kenji
Koga, Masafumi
Shinozaki, Hiroyuki
Yamauchi, Mototaka
Suzuki, Tatsuhiko
Naruse, Rika
Tsuchiya, Takafumi
Takebayashi, Kohzo
Inukai, Toshihiko
Hashimoto, Koshi
author_facet Hara, Kenji
Koga, Masafumi
Shinozaki, Hiroyuki
Yamauchi, Mototaka
Suzuki, Tatsuhiko
Naruse, Rika
Tsuchiya, Takafumi
Takebayashi, Kohzo
Inukai, Toshihiko
Hashimoto, Koshi
author_sort Hara, Kenji
collection PubMed
description We herein report a 50-year-old Chinese woman with Hb Phnom Penh (α117Phe-Ile-α118Thr) showing high or reasonable HbA1c values depending on the type of high-performance liquid chromatography (HPLC) system. A high HbA1c value of 7.5% (HPLC assay: G9) and a reasonable HbA1c value of 5.2% (assay unknown) were observed. Therefore, the patient was refereed to our hospital; the oral glucose tolerance test showed normal glucose tolerance. The HbA1c values measured by an enzymatic assay, immunoassay, and affinity assay, as well as most HPLC assays were within the reference range, whereas those measured by the Tosoh HPLC systems were high.
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spelling pubmed-71183872020-04-07 Hb Phnom Penh Showing Falsely High or Reasonable HbA1c Values Depending on the Type of High-performance Liquid Chromatography System Hara, Kenji Koga, Masafumi Shinozaki, Hiroyuki Yamauchi, Mototaka Suzuki, Tatsuhiko Naruse, Rika Tsuchiya, Takafumi Takebayashi, Kohzo Inukai, Toshihiko Hashimoto, Koshi Intern Med Case Report We herein report a 50-year-old Chinese woman with Hb Phnom Penh (α117Phe-Ile-α118Thr) showing high or reasonable HbA1c values depending on the type of high-performance liquid chromatography (HPLC) system. A high HbA1c value of 7.5% (HPLC assay: G9) and a reasonable HbA1c value of 5.2% (assay unknown) were observed. Therefore, the patient was refereed to our hospital; the oral glucose tolerance test showed normal glucose tolerance. The HbA1c values measured by an enzymatic assay, immunoassay, and affinity assay, as well as most HPLC assays were within the reference range, whereas those measured by the Tosoh HPLC systems were high. The Japanese Society of Internal Medicine 2019-11-29 2020-03-15 /pmc/articles/PMC7118387/ /pubmed/31787693 http://dx.doi.org/10.2169/internalmedicine.3306-19 Text en Copyright © 2020 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Hara, Kenji
Koga, Masafumi
Shinozaki, Hiroyuki
Yamauchi, Mototaka
Suzuki, Tatsuhiko
Naruse, Rika
Tsuchiya, Takafumi
Takebayashi, Kohzo
Inukai, Toshihiko
Hashimoto, Koshi
Hb Phnom Penh Showing Falsely High or Reasonable HbA1c Values Depending on the Type of High-performance Liquid Chromatography System
title Hb Phnom Penh Showing Falsely High or Reasonable HbA1c Values Depending on the Type of High-performance Liquid Chromatography System
title_full Hb Phnom Penh Showing Falsely High or Reasonable HbA1c Values Depending on the Type of High-performance Liquid Chromatography System
title_fullStr Hb Phnom Penh Showing Falsely High or Reasonable HbA1c Values Depending on the Type of High-performance Liquid Chromatography System
title_full_unstemmed Hb Phnom Penh Showing Falsely High or Reasonable HbA1c Values Depending on the Type of High-performance Liquid Chromatography System
title_short Hb Phnom Penh Showing Falsely High or Reasonable HbA1c Values Depending on the Type of High-performance Liquid Chromatography System
title_sort hb phnom penh showing falsely high or reasonable hba1c values depending on the type of high-performance liquid chromatography system
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7118387/
https://www.ncbi.nlm.nih.gov/pubmed/31787693
http://dx.doi.org/10.2169/internalmedicine.3306-19
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