Cargando…

A case of lymphangioleiomyomatosis with diffuse large B-cell lymphoma: Usefulness of FDG-PET

Lymphangioleiomyomatosis (LAM) is characterized by cystic lung disease, abdominal tumor and involvement of the axial lymph nodes. We report a very rare case of LAM with malignant lymphoma. A 51-year-old female had medical history of recurrent pneumothorax and nephrectomy for a left renal angiomyolip...

Descripción completa

Detalles Bibliográficos
Autores principales: Orimo, Mami, Kondo, Mitsuko, Takeyama, Kiyoshi, Masui, Kenta, Tanaka, Junji, Tagaya, Etsuko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7118407/
https://www.ncbi.nlm.nih.gov/pubmed/32257785
http://dx.doi.org/10.1016/j.rmcr.2020.100999
_version_ 1783514557619109888
author Orimo, Mami
Kondo, Mitsuko
Takeyama, Kiyoshi
Masui, Kenta
Tanaka, Junji
Tagaya, Etsuko
author_facet Orimo, Mami
Kondo, Mitsuko
Takeyama, Kiyoshi
Masui, Kenta
Tanaka, Junji
Tagaya, Etsuko
author_sort Orimo, Mami
collection PubMed
description Lymphangioleiomyomatosis (LAM) is characterized by cystic lung disease, abdominal tumor and involvement of the axial lymph nodes. We report a very rare case of LAM with malignant lymphoma. A 51-year-old female had medical history of recurrent pneumothorax and nephrectomy for a left renal angiomyolipoma and was diagnosed with LAM by video-assisted thoracoscopic surgery at the age of 30. She presented with left neck mass. Computed tomography and magnetic response imaging showed multiple enlarged cervical lymph nodes. (18)F-fluorodeoxyglucose-positron emission tomography (FDG-PET) showed abnormal uptake in the mass. We suspected a malignant tumor or extrapulmonary lesion of LAM, and performed surgical biopsy. Pathologically, diffuse large B-cell lymphoma was diagnosed, but LAM was not detected. After she received six cycles of R–CHOP chemotherapy, FDG-PET turned negative and complete metabolic response was achieved. As LAM is reported to be silent for FDG-PET, unusual uptake of FDG is useful for identifying other neoplasms. For this case, FDG-PET was useful for the differential diagnosis and therapeutic evaluation.
format Online
Article
Text
id pubmed-7118407
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-71184072020-04-06 A case of lymphangioleiomyomatosis with diffuse large B-cell lymphoma: Usefulness of FDG-PET Orimo, Mami Kondo, Mitsuko Takeyama, Kiyoshi Masui, Kenta Tanaka, Junji Tagaya, Etsuko Respir Med Case Rep Case Report Lymphangioleiomyomatosis (LAM) is characterized by cystic lung disease, abdominal tumor and involvement of the axial lymph nodes. We report a very rare case of LAM with malignant lymphoma. A 51-year-old female had medical history of recurrent pneumothorax and nephrectomy for a left renal angiomyolipoma and was diagnosed with LAM by video-assisted thoracoscopic surgery at the age of 30. She presented with left neck mass. Computed tomography and magnetic response imaging showed multiple enlarged cervical lymph nodes. (18)F-fluorodeoxyglucose-positron emission tomography (FDG-PET) showed abnormal uptake in the mass. We suspected a malignant tumor or extrapulmonary lesion of LAM, and performed surgical biopsy. Pathologically, diffuse large B-cell lymphoma was diagnosed, but LAM was not detected. After she received six cycles of R–CHOP chemotherapy, FDG-PET turned negative and complete metabolic response was achieved. As LAM is reported to be silent for FDG-PET, unusual uptake of FDG is useful for identifying other neoplasms. For this case, FDG-PET was useful for the differential diagnosis and therapeutic evaluation. Elsevier 2020-01-16 /pmc/articles/PMC7118407/ /pubmed/32257785 http://dx.doi.org/10.1016/j.rmcr.2020.100999 Text en © 2020 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Orimo, Mami
Kondo, Mitsuko
Takeyama, Kiyoshi
Masui, Kenta
Tanaka, Junji
Tagaya, Etsuko
A case of lymphangioleiomyomatosis with diffuse large B-cell lymphoma: Usefulness of FDG-PET
title A case of lymphangioleiomyomatosis with diffuse large B-cell lymphoma: Usefulness of FDG-PET
title_full A case of lymphangioleiomyomatosis with diffuse large B-cell lymphoma: Usefulness of FDG-PET
title_fullStr A case of lymphangioleiomyomatosis with diffuse large B-cell lymphoma: Usefulness of FDG-PET
title_full_unstemmed A case of lymphangioleiomyomatosis with diffuse large B-cell lymphoma: Usefulness of FDG-PET
title_short A case of lymphangioleiomyomatosis with diffuse large B-cell lymphoma: Usefulness of FDG-PET
title_sort case of lymphangioleiomyomatosis with diffuse large b-cell lymphoma: usefulness of fdg-pet
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7118407/
https://www.ncbi.nlm.nih.gov/pubmed/32257785
http://dx.doi.org/10.1016/j.rmcr.2020.100999
work_keys_str_mv AT orimomami acaseoflymphangioleiomyomatosiswithdiffuselargebcelllymphomausefulnessoffdgpet
AT kondomitsuko acaseoflymphangioleiomyomatosiswithdiffuselargebcelllymphomausefulnessoffdgpet
AT takeyamakiyoshi acaseoflymphangioleiomyomatosiswithdiffuselargebcelllymphomausefulnessoffdgpet
AT masuikenta acaseoflymphangioleiomyomatosiswithdiffuselargebcelllymphomausefulnessoffdgpet
AT tanakajunji acaseoflymphangioleiomyomatosiswithdiffuselargebcelllymphomausefulnessoffdgpet
AT tagayaetsuko acaseoflymphangioleiomyomatosiswithdiffuselargebcelllymphomausefulnessoffdgpet
AT orimomami caseoflymphangioleiomyomatosiswithdiffuselargebcelllymphomausefulnessoffdgpet
AT kondomitsuko caseoflymphangioleiomyomatosiswithdiffuselargebcelllymphomausefulnessoffdgpet
AT takeyamakiyoshi caseoflymphangioleiomyomatosiswithdiffuselargebcelllymphomausefulnessoffdgpet
AT masuikenta caseoflymphangioleiomyomatosiswithdiffuselargebcelllymphomausefulnessoffdgpet
AT tanakajunji caseoflymphangioleiomyomatosiswithdiffuselargebcelllymphomausefulnessoffdgpet
AT tagayaetsuko caseoflymphangioleiomyomatosiswithdiffuselargebcelllymphomausefulnessoffdgpet