Cargando…

Factors associated with multi-drug-resistant tuberculosis in Dakar, Senegal, 2010-2016

According to the World Health Organization, multidrug-resistant tuberculosis (MDR-TB) represents a major obstacle towards successful TB treatment and control. In Dakar, MDR-TB management began in 2010 with the strengthening of diagnostic resources. The objective of this study was to identify the fac...

Descripción completa

Detalles Bibliográficos
Autores principales: Ndiaye, Mbouna, Yanogo, Pauline Kiswendsida, Sawadogo, Bernard, Diallo, Fadima, Antara, Simon, Meda, Nicolas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PAGEPress Publications, Pavia, Italy 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7118427/
https://www.ncbi.nlm.nih.gov/pubmed/32257080
http://dx.doi.org/10.4081/jphia.2019.1099
_version_ 1783514561448509440
author Ndiaye, Mbouna
Yanogo, Pauline Kiswendsida
Sawadogo, Bernard
Diallo, Fadima
Antara, Simon
Meda, Nicolas
author_facet Ndiaye, Mbouna
Yanogo, Pauline Kiswendsida
Sawadogo, Bernard
Diallo, Fadima
Antara, Simon
Meda, Nicolas
author_sort Ndiaye, Mbouna
collection PubMed
description According to the World Health Organization, multidrug-resistant tuberculosis (MDR-TB) represents a major obstacle towards successful TB treatment and control. In Dakar, MDR-TB management began in 2010 with the strengthening of diagnostic resources. The objective of this study was to identify the factors associated with multidrug-resistant tuberculosis in Dakar between 2010 and 2016. We conducted a case-control study from January 10 to February 28, 2017 in tuberculosis centers in Dakar. of 169 cases and 507 controls. We used logistic regression with Epi-info version 7.2.1. to estimate the odds ratios of association. Factors significantly associated with MDR-TB were: residing in a periurban area (ORa=1.8; 95% CI (1.5-4.9); p=0.024), presence of MDR-TB in the entourage of patient (ORa=7.0; 95% CI (6.1-9.5); p=0.002), previous treatment failure (ORa=29.5; 95% CI (27.3-30.1); p=0.000), treatment not directly observed by a health care provider (ORa=4.3; 95% CI (4.1-7,2); p=0.000) and irregularity of treatment (ORa=1.7; 95% CI (0.5-5.4); p=0.037). Focusing interventions on population at-risk will prevent MDR-TB.
format Online
Article
Text
id pubmed-7118427
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher PAGEPress Publications, Pavia, Italy
record_format MEDLINE/PubMed
spelling pubmed-71184272020-04-06 Factors associated with multi-drug-resistant tuberculosis in Dakar, Senegal, 2010-2016 Ndiaye, Mbouna Yanogo, Pauline Kiswendsida Sawadogo, Bernard Diallo, Fadima Antara, Simon Meda, Nicolas J Public Health Afr Article According to the World Health Organization, multidrug-resistant tuberculosis (MDR-TB) represents a major obstacle towards successful TB treatment and control. In Dakar, MDR-TB management began in 2010 with the strengthening of diagnostic resources. The objective of this study was to identify the factors associated with multidrug-resistant tuberculosis in Dakar between 2010 and 2016. We conducted a case-control study from January 10 to February 28, 2017 in tuberculosis centers in Dakar. of 169 cases and 507 controls. We used logistic regression with Epi-info version 7.2.1. to estimate the odds ratios of association. Factors significantly associated with MDR-TB were: residing in a periurban area (ORa=1.8; 95% CI (1.5-4.9); p=0.024), presence of MDR-TB in the entourage of patient (ORa=7.0; 95% CI (6.1-9.5); p=0.002), previous treatment failure (ORa=29.5; 95% CI (27.3-30.1); p=0.000), treatment not directly observed by a health care provider (ORa=4.3; 95% CI (4.1-7,2); p=0.000) and irregularity of treatment (ORa=1.7; 95% CI (0.5-5.4); p=0.037). Focusing interventions on population at-risk will prevent MDR-TB. PAGEPress Publications, Pavia, Italy 2020-03-20 /pmc/articles/PMC7118427/ /pubmed/32257080 http://dx.doi.org/10.4081/jphia.2019.1099 Text en ©Copyright: the Author(s), 2019 http://creativecommons.org/licenses/by-nc/4.0/ This work is licensed under a Creative Commons Attribution NonCommercial 4.0 License (CC BY-NC 4.0).
spellingShingle Article
Ndiaye, Mbouna
Yanogo, Pauline Kiswendsida
Sawadogo, Bernard
Diallo, Fadima
Antara, Simon
Meda, Nicolas
Factors associated with multi-drug-resistant tuberculosis in Dakar, Senegal, 2010-2016
title Factors associated with multi-drug-resistant tuberculosis in Dakar, Senegal, 2010-2016
title_full Factors associated with multi-drug-resistant tuberculosis in Dakar, Senegal, 2010-2016
title_fullStr Factors associated with multi-drug-resistant tuberculosis in Dakar, Senegal, 2010-2016
title_full_unstemmed Factors associated with multi-drug-resistant tuberculosis in Dakar, Senegal, 2010-2016
title_short Factors associated with multi-drug-resistant tuberculosis in Dakar, Senegal, 2010-2016
title_sort factors associated with multi-drug-resistant tuberculosis in dakar, senegal, 2010-2016
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7118427/
https://www.ncbi.nlm.nih.gov/pubmed/32257080
http://dx.doi.org/10.4081/jphia.2019.1099
work_keys_str_mv AT ndiayembouna factorsassociatedwithmultidrugresistanttuberculosisindakarsenegal20102016
AT yanogopaulinekiswendsida factorsassociatedwithmultidrugresistanttuberculosisindakarsenegal20102016
AT sawadogobernard factorsassociatedwithmultidrugresistanttuberculosisindakarsenegal20102016
AT diallofadima factorsassociatedwithmultidrugresistanttuberculosisindakarsenegal20102016
AT antarasimon factorsassociatedwithmultidrugresistanttuberculosisindakarsenegal20102016
AT medanicolas factorsassociatedwithmultidrugresistanttuberculosisindakarsenegal20102016