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Factors associated with multi-drug-resistant tuberculosis in Dakar, Senegal, 2010-2016
According to the World Health Organization, multidrug-resistant tuberculosis (MDR-TB) represents a major obstacle towards successful TB treatment and control. In Dakar, MDR-TB management began in 2010 with the strengthening of diagnostic resources. The objective of this study was to identify the fac...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
PAGEPress Publications, Pavia, Italy
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7118427/ https://www.ncbi.nlm.nih.gov/pubmed/32257080 http://dx.doi.org/10.4081/jphia.2019.1099 |
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author | Ndiaye, Mbouna Yanogo, Pauline Kiswendsida Sawadogo, Bernard Diallo, Fadima Antara, Simon Meda, Nicolas |
author_facet | Ndiaye, Mbouna Yanogo, Pauline Kiswendsida Sawadogo, Bernard Diallo, Fadima Antara, Simon Meda, Nicolas |
author_sort | Ndiaye, Mbouna |
collection | PubMed |
description | According to the World Health Organization, multidrug-resistant tuberculosis (MDR-TB) represents a major obstacle towards successful TB treatment and control. In Dakar, MDR-TB management began in 2010 with the strengthening of diagnostic resources. The objective of this study was to identify the factors associated with multidrug-resistant tuberculosis in Dakar between 2010 and 2016. We conducted a case-control study from January 10 to February 28, 2017 in tuberculosis centers in Dakar. of 169 cases and 507 controls. We used logistic regression with Epi-info version 7.2.1. to estimate the odds ratios of association. Factors significantly associated with MDR-TB were: residing in a periurban area (ORa=1.8; 95% CI (1.5-4.9); p=0.024), presence of MDR-TB in the entourage of patient (ORa=7.0; 95% CI (6.1-9.5); p=0.002), previous treatment failure (ORa=29.5; 95% CI (27.3-30.1); p=0.000), treatment not directly observed by a health care provider (ORa=4.3; 95% CI (4.1-7,2); p=0.000) and irregularity of treatment (ORa=1.7; 95% CI (0.5-5.4); p=0.037). Focusing interventions on population at-risk will prevent MDR-TB. |
format | Online Article Text |
id | pubmed-7118427 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | PAGEPress Publications, Pavia, Italy |
record_format | MEDLINE/PubMed |
spelling | pubmed-71184272020-04-06 Factors associated with multi-drug-resistant tuberculosis in Dakar, Senegal, 2010-2016 Ndiaye, Mbouna Yanogo, Pauline Kiswendsida Sawadogo, Bernard Diallo, Fadima Antara, Simon Meda, Nicolas J Public Health Afr Article According to the World Health Organization, multidrug-resistant tuberculosis (MDR-TB) represents a major obstacle towards successful TB treatment and control. In Dakar, MDR-TB management began in 2010 with the strengthening of diagnostic resources. The objective of this study was to identify the factors associated with multidrug-resistant tuberculosis in Dakar between 2010 and 2016. We conducted a case-control study from January 10 to February 28, 2017 in tuberculosis centers in Dakar. of 169 cases and 507 controls. We used logistic regression with Epi-info version 7.2.1. to estimate the odds ratios of association. Factors significantly associated with MDR-TB were: residing in a periurban area (ORa=1.8; 95% CI (1.5-4.9); p=0.024), presence of MDR-TB in the entourage of patient (ORa=7.0; 95% CI (6.1-9.5); p=0.002), previous treatment failure (ORa=29.5; 95% CI (27.3-30.1); p=0.000), treatment not directly observed by a health care provider (ORa=4.3; 95% CI (4.1-7,2); p=0.000) and irregularity of treatment (ORa=1.7; 95% CI (0.5-5.4); p=0.037). Focusing interventions on population at-risk will prevent MDR-TB. PAGEPress Publications, Pavia, Italy 2020-03-20 /pmc/articles/PMC7118427/ /pubmed/32257080 http://dx.doi.org/10.4081/jphia.2019.1099 Text en ©Copyright: the Author(s), 2019 http://creativecommons.org/licenses/by-nc/4.0/ This work is licensed under a Creative Commons Attribution NonCommercial 4.0 License (CC BY-NC 4.0). |
spellingShingle | Article Ndiaye, Mbouna Yanogo, Pauline Kiswendsida Sawadogo, Bernard Diallo, Fadima Antara, Simon Meda, Nicolas Factors associated with multi-drug-resistant tuberculosis in Dakar, Senegal, 2010-2016 |
title | Factors associated with multi-drug-resistant tuberculosis in Dakar, Senegal, 2010-2016 |
title_full | Factors associated with multi-drug-resistant tuberculosis in Dakar, Senegal, 2010-2016 |
title_fullStr | Factors associated with multi-drug-resistant tuberculosis in Dakar, Senegal, 2010-2016 |
title_full_unstemmed | Factors associated with multi-drug-resistant tuberculosis in Dakar, Senegal, 2010-2016 |
title_short | Factors associated with multi-drug-resistant tuberculosis in Dakar, Senegal, 2010-2016 |
title_sort | factors associated with multi-drug-resistant tuberculosis in dakar, senegal, 2010-2016 |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7118427/ https://www.ncbi.nlm.nih.gov/pubmed/32257080 http://dx.doi.org/10.4081/jphia.2019.1099 |
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