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Combined exposure to dinotefuran and chronic mild stress counteracts the change of the emotional and monoaminergic neuronal activity induced by either exposure singly despite corticosterone elevation in mice

Dinotefuran (DIN) belongs to the neonicotinoids (NNs), a class of globally applied pesticides originally developed to exhibit selective toxicity in insects. However, several reports have suggested that NNs also exert neurotoxic effects in mammals. We previously demonstrated neurobehavioral effects o...

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Autores principales: TAKADA, Tadashi, YONEDA, Naoki, HIRANO, Tetsushi, ONARU, Kanoko, MANTANI, Youhei, YOKOYAMA, Toshifumi, KITAGAWA, Hiroshi, TABUCHI, Yoshiaki, NIMAKO, Collins, ISHIZUKA, Mayumi, IKENAKA, Yoshinori, HOSHI, Nobuhiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Veterinary Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7118473/
https://www.ncbi.nlm.nih.gov/pubmed/31983702
http://dx.doi.org/10.1292/jvms.19-0635
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author TAKADA, Tadashi
YONEDA, Naoki
HIRANO, Tetsushi
ONARU, Kanoko
MANTANI, Youhei
YOKOYAMA, Toshifumi
KITAGAWA, Hiroshi
TABUCHI, Yoshiaki
NIMAKO, Collins
ISHIZUKA, Mayumi
IKENAKA, Yoshinori
HOSHI, Nobuhiko
author_facet TAKADA, Tadashi
YONEDA, Naoki
HIRANO, Tetsushi
ONARU, Kanoko
MANTANI, Youhei
YOKOYAMA, Toshifumi
KITAGAWA, Hiroshi
TABUCHI, Yoshiaki
NIMAKO, Collins
ISHIZUKA, Mayumi
IKENAKA, Yoshinori
HOSHI, Nobuhiko
author_sort TAKADA, Tadashi
collection PubMed
description Dinotefuran (DIN) belongs to the neonicotinoids (NNs), a class of globally applied pesticides originally developed to exhibit selective toxicity in insects. However, several reports have suggested that NNs also exert neurotoxic effects in mammals. We previously demonstrated neurobehavioral effects of DIN on mice under non-stressful conditions. For further toxicity assessments in the present study, we investigated the effects of DIN on mice exposed to stressful conditions. After subacutely administering a no-observed-effect-level (NOEL) dose of DIN and/or chronic unpredictable mild stress (CUMS) to mice, we conducted three behavioral tests (i.e., open field test [OFT], tail suspension test [TST] and forced swimming test [FST]). In addition, serotonin (5-HT) and tryptophan hydroxylase 2 (TPH2) of the dorsal raphe nuclei (DRN) and median raphe nuclei (MRN) and tyrosine hydroxylase (TH) of the ventral tegmental area and substantia nigra (SN) were evaluated immunohistochemically. A NOEL dose of DIN or CUMS alone increased of the total distance in OFT, decreased or increased the immobility time in TST or FST, respectively, and increased the positive intensity of 5-HT and TPH2 in the DRN/MRN, and TH in the SN. These changes were suppressed under the conditions of combined exposure to DIN and CUMS, though the blood corticosterone level was increased depending on the blood DIN values and the presence of CUMS. The present study suggests the multifaceted toxicity of the neurotoxin DIN.
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spelling pubmed-71184732020-04-08 Combined exposure to dinotefuran and chronic mild stress counteracts the change of the emotional and monoaminergic neuronal activity induced by either exposure singly despite corticosterone elevation in mice TAKADA, Tadashi YONEDA, Naoki HIRANO, Tetsushi ONARU, Kanoko MANTANI, Youhei YOKOYAMA, Toshifumi KITAGAWA, Hiroshi TABUCHI, Yoshiaki NIMAKO, Collins ISHIZUKA, Mayumi IKENAKA, Yoshinori HOSHI, Nobuhiko J Vet Med Sci Toxicology Dinotefuran (DIN) belongs to the neonicotinoids (NNs), a class of globally applied pesticides originally developed to exhibit selective toxicity in insects. However, several reports have suggested that NNs also exert neurotoxic effects in mammals. We previously demonstrated neurobehavioral effects of DIN on mice under non-stressful conditions. For further toxicity assessments in the present study, we investigated the effects of DIN on mice exposed to stressful conditions. After subacutely administering a no-observed-effect-level (NOEL) dose of DIN and/or chronic unpredictable mild stress (CUMS) to mice, we conducted three behavioral tests (i.e., open field test [OFT], tail suspension test [TST] and forced swimming test [FST]). In addition, serotonin (5-HT) and tryptophan hydroxylase 2 (TPH2) of the dorsal raphe nuclei (DRN) and median raphe nuclei (MRN) and tyrosine hydroxylase (TH) of the ventral tegmental area and substantia nigra (SN) were evaluated immunohistochemically. A NOEL dose of DIN or CUMS alone increased of the total distance in OFT, decreased or increased the immobility time in TST or FST, respectively, and increased the positive intensity of 5-HT and TPH2 in the DRN/MRN, and TH in the SN. These changes were suppressed under the conditions of combined exposure to DIN and CUMS, though the blood corticosterone level was increased depending on the blood DIN values and the presence of CUMS. The present study suggests the multifaceted toxicity of the neurotoxin DIN. The Japanese Society of Veterinary Science 2020-01-27 2020-03 /pmc/articles/PMC7118473/ /pubmed/31983702 http://dx.doi.org/10.1292/jvms.19-0635 Text en ©2020 The Japanese Society of Veterinary Science This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle Toxicology
TAKADA, Tadashi
YONEDA, Naoki
HIRANO, Tetsushi
ONARU, Kanoko
MANTANI, Youhei
YOKOYAMA, Toshifumi
KITAGAWA, Hiroshi
TABUCHI, Yoshiaki
NIMAKO, Collins
ISHIZUKA, Mayumi
IKENAKA, Yoshinori
HOSHI, Nobuhiko
Combined exposure to dinotefuran and chronic mild stress counteracts the change of the emotional and monoaminergic neuronal activity induced by either exposure singly despite corticosterone elevation in mice
title Combined exposure to dinotefuran and chronic mild stress counteracts the change of the emotional and monoaminergic neuronal activity induced by either exposure singly despite corticosterone elevation in mice
title_full Combined exposure to dinotefuran and chronic mild stress counteracts the change of the emotional and monoaminergic neuronal activity induced by either exposure singly despite corticosterone elevation in mice
title_fullStr Combined exposure to dinotefuran and chronic mild stress counteracts the change of the emotional and monoaminergic neuronal activity induced by either exposure singly despite corticosterone elevation in mice
title_full_unstemmed Combined exposure to dinotefuran and chronic mild stress counteracts the change of the emotional and monoaminergic neuronal activity induced by either exposure singly despite corticosterone elevation in mice
title_short Combined exposure to dinotefuran and chronic mild stress counteracts the change of the emotional and monoaminergic neuronal activity induced by either exposure singly despite corticosterone elevation in mice
title_sort combined exposure to dinotefuran and chronic mild stress counteracts the change of the emotional and monoaminergic neuronal activity induced by either exposure singly despite corticosterone elevation in mice
topic Toxicology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7118473/
https://www.ncbi.nlm.nih.gov/pubmed/31983702
http://dx.doi.org/10.1292/jvms.19-0635
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