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Intravenously Administered, Retinoid Activating Nanoparticles Increase Lifespan and Reduce Neurodegeneration in the SOD1(G93A) Mouse Model of ALS

Dysregulation of the retinoic acid (RA) signaling pathway is observed in amyotrophic lateral sclerosis (ALS) and other neurodegenerative disorders. Here, we investigated the therapeutic potential of retinoid activation via the RA receptor β (RARβ) in the SOD1(G93A) mouse model of ALS. Our approach u...

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Detalles Bibliográficos
Autores principales:	Medina, David X., Chung, Eugene P., Teague, Collin D., Bowser, Robert, Sirianni, Rachael W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Bioengineering and Biotechnology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7118553/ https://www.ncbi.nlm.nih.gov/pubmed/32292776 http://dx.doi.org/10.3389/fbioe.2020.00224

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